Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, Tampa, Florida.
Cancer Epidemiol Biomarkers Prev. 2020 Jan;29(1):39-48. doi: 10.1158/1055-9965.EPI-19-0446. Epub 2019 Aug 19.
Accumulating evidence suggests that cutaneous viral infections are risk factors for the development of keratinocyte carcinomas. The Viruses in Skin Cancer (VIRUSCAN) Study, a prospective cohort study, was established in 2014 to investigate the risk of keratinocyte carcinoma associated with cutaneous human papillomavirus and polyomavirus infection and the possible interaction with ultraviolet radiation exposure (UVR).
METHODS/RESULTS: VIRUSCAN incorporates repeated measures of viral infection using multiple markers of infection and quantitative measures of UVR using a spectrophotometer. Participants were recruited between July 14, 2014 and August 31, 2017 at the University of South Florida Dermatology Clinic in Tampa, FL. After excluding 124 individuals with prevalent keratinocyte carcinomas at baseline, 1,179 participants (53.2% women, 46.8% men, all ages 60 years and older) were followed for up to 4 years with routine skin exams occurring every 6 to 12 months. Here, we present the VIRUSCAN Study design, methods, and baseline characteristics, including demographics, sun exposure behavior, quantitative UVR exposure measurements, and cutaneous viral prevalence, for the full study cohort.
The VIRUSCAN Study will provide critical temporal evidence needed to assess the causality of the role cutaneous viral infections play in the development of keratinocyte carcinomas, as well as the potential interaction between cutaneous viral infections and UVR exposure.
Study findings will be valuable in future development of novel keratinocyte carcinoma prevention strategies.
越来越多的证据表明，皮肤病毒感染是角质细胞癌发展的危险因素。VIRUSCAN 研究是一项前瞻性队列研究，成立于 2014 年，旨在研究与皮肤人乳头瘤病毒和多瘤病毒感染相关的角质细胞癌风险，以及与紫外线辐射暴露（UVR）的可能相互作用。
方法/结果：VIRUSCAN 使用多种感染标志物和分光光度计对 UVR 进行定量测量，对病毒感染进行重复测量。参与者于 2014 年 7 月 14 日至 2017 年 8 月 31 日在佛罗里达州坦帕市南佛罗里达大学皮肤科诊所招募。在排除基线时患有现患角质细胞癌的 124 人后，1179 名参与者（53.2%女性，46.8%男性，年龄均在 60 岁及以上）接受了长达 4 年的随访，每 6 至 12 个月进行一次常规皮肤检查。在这里，我们介绍了 VIRUSCAN 研究的设计、方法和基线特征，包括人口统计学、阳光暴露行为、定量 UVR 暴露测量以及皮肤病毒流行情况，涵盖了整个研究队列。
VIRUSCAN 研究将提供评估皮肤病毒感染在角质细胞癌发展中的因果作用以及皮肤病毒感染与 UVR 暴露之间潜在相互作用所需的关键时间证据。
研究结果将对未来开发新型角质细胞癌预防策略具有重要价值。
