载有超顺磁氧化铁和紫杉醇的癌细胞膜包覆介孔硅用于 MDA-MB-231 细胞的化疗/磁热疗联合治疗。
Cancer cell membrane-coated mesoporous silica loaded with superparamagnetic ferroferric oxide and Paclitaxel for the combination of Chemo/Magnetocaloric therapy on MDA-MB-231 cells.
机构信息
Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 161006, China.
College of Pharmacy, Qiqihar Medical University, Qiqihar, 161006, China.
出版信息
Sci Rep. 2019 Oct 9;9(1):14475. doi: 10.1038/s41598-019-51029-8.
To effectively inhibit the growth of breast cancer cells (MDA-MB-231 cells) by the combination method of chemotherapy and magnetic hyperthermia, we fabricated a biomimetic drug delivery (CSiFePNs) system composed of mesoporous silica nanoparticles (MSNs) containing superparamagnetic ferroferric oxide and Paclitaxel (PTX) coated with MDA-MB-231 cell membranes (CMs). In the in vitro cytotoxicity tests, the MDA-MB-231 cells incubated with CSiFePNs obtained IC value of 0.8 μgL, 3.5-fold higher than that of SiFePNs. The combination method of chemotherapy and magnetic hyperthermia can effectively inhibit the growth of MDA-MB-231 cells.
为了通过化疗和磁热疗的联合方法有效抑制乳腺癌细胞（MDA-MB-231 细胞）的生长，我们制备了一种仿生药物输送（CSiFePNs）系统，该系统由介孔硅纳米粒子（MSNs）组成，其中包含超顺磁性氧化铁和紫杉醇（PTX），并涂覆有 MDA-MB-231 细胞膜（CMs）。在体外细胞毒性试验中，用 CSiFePNs 孵育的 MDA-MB-231 细胞的 IC 值为 0.8 μgL，比 SiFePNs 高 3.5 倍。化疗和磁热疗的联合方法可以有效抑制 MDA-MB-231 细胞的生长。
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