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CBA/N小鼠中B细胞的个体发生。发育过程中对胸腺非依赖性抗原反应阶段的证据。

Ontogeny of B cells in CBA/N mice. Evidence for a stage of responsiveness to thymus-independent antigens during development.

作者信息

Lindsten T, Andersson B

出版信息

J Exp Med. 1979 Dec 1;150(6):1285-92. doi: 10.1084/jem.150.6.1285.

DOI:10.1084/jem.150.6.1285
PMID:315989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185722/
Abstract

This paper deals with the CBA/N mice, a strain bearing a genetic defect in their B-cell compartment. By using a previously described system we have been able to show that the immature cells of CBA/N mice are functionally indistinguishable from normal immature cells, in that both can be triggered to respond to thymus-independent (TI) antigens, provided they are supplied with helper T cells. When the maturation is completed, CBA/N B cells are unable to respond to TI antigens (like lipopolysaccharide and polyvinyl pyrrolidine) irrespective of the presence of helper T cells, whereas normal mature B cells have grown able to respond without any help. These data allow us to reject the hypothesis that CBA/N mice are arrested at an immature stage and clearly support the idea that they have deviated during development so that only thymus-dependent B cells develop.

摘要

本文研究的是CBA/N小鼠，这是一种在B细胞区室存在基因缺陷的品系。通过使用先前描述的系统，我们已经能够表明，CBA/N小鼠的未成熟细胞在功能上与正常未成熟细胞没有区别，因为只要提供辅助性T细胞，两者都能被触发对非胸腺依赖性（TI）抗原作出反应。当成熟完成时，无论是否存在辅助性T细胞，CBA/N B细胞都无法对TI抗原（如脂多糖和聚乙烯吡咯烷）作出反应，而正常成熟B细胞已经能够在没有任何帮助的情况下作出反应。这些数据使我们能够否定CBA/N小鼠停滞在未成熟阶段的假设，并明确支持这样一种观点，即它们在发育过程中发生了偏差，以至于只有胸腺依赖性B细胞得以发育。

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本文引用的文献

1
The carrier effect in the secondary response to hapten-protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis.对半抗原-蛋白质偶联物二次反应中的载体效应。I. 用转移细胞测量效应及对局部环境假说的异议
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Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide.小鼠体内针对聚乙烯吡咯烷酮和大肠杆菌脂多糖的非胸腺依赖性体液抗体产生的证据。
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3
Functional characteristics of Peyer's patch lymphoid cells. II. Lipopolysaccharide is thymus dependent.派尔集合淋巴结淋巴细胞的功能特性。II. 脂多糖依赖胸腺。
J Exp Med. 1974 Feb 1;139(2):407-13. doi: 10.1084/jem.139.2.407.
4
Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness.小鼠对3型肺炎球菌多糖抗体反应的遗传控制。I. 有证据表明一个X连锁基因在决定反应性方面起决定性作用。
J Exp Med. 1972 Oct 1;136(4):931-49. doi: 10.1084/jem.136.4.931.
5
The genetics of the immune response to a synthetic double-stranded RNA in a mutant CBA mouse strain.突变CBA小鼠品系对合成双链RNA免疫反应的遗传学研究
J Immunol. 1973 May;110(5):1396-401.
6
Functional analysis of murine and human B lymphocyte subsets.小鼠和人类B淋巴细胞亚群的功能分析。
Transplant Rev. 1975;24:177-236. doi: 10.1111/j.1600-065x.1975.tb00169.x.
7
T-cell dependency of the response to PVP is dependent on maturity of B-cells.对聚乙烯吡咯烷酮（PVP）反应的T细胞依赖性取决于B细胞的成熟度。
Adv Exp Med Biol. 1976;66:283-8. doi: 10.1007/978-1-4613-4355-4_42.
8
X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect.CBA/N小鼠的X连锁B淋巴细胞免疫缺陷。II.免疫缺陷潜在机制的研究。
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9
T-cell response to polyvinyl pyrrolidone is linked to maturity of B cells.T细胞对聚乙烯吡咯烷酮的反应与B细胞的成熟度相关。
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