胆红素保护心肾代谢疾病：健康中的保护作用。
Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health.
机构信息
Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, 43614, USA.
Department of Physiology & Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, 2500 North State St, Jackson, MS, 39216, USA.
出版信息
Curr Hypertens Rep. 2019 Oct 10;21(11):87. doi: 10.1007/s11906-019-0994-z.
Abstract
PURPOSE OF REVIEW
To discuss recent advances indicating that bilirubin safeguards against cardiorenal and metabolic diseases.
RECENT FINDINGS
Several investigations from human patient populations and experimental animal models have shown that bilirubin improves cardiorenal and metabolic dysfunction. The latest studies found an entirely new function of bilirubin suggesting that it acts as a hormone signaling molecule capable of activating nuclear receptors for burning fat, which may explain several of its protective actions. This review highlights the current findings (within the last 3 years) regarding cardiorenal and metabolic protective effects of bilirubin and the latest mechanism(s) that may be mediating these effects.
摘要
目的综述
探讨胆红素具有保护心肾和代谢疾病作用的最新进展。
最新发现
来自人类患者群体和实验动物模型的多项研究表明，胆红素可改善心肾和代谢功能障碍。最新研究发现胆红素具有全新的功能，提示其作为一种激素信号分子，能够激活脂肪燃烧的核受体，这或许可以解释其部分保护作用。本综述重点介绍胆红素具有心肾和代谢保护作用的最新发现（在过去 3 年内），以及可能介导这些作用的最新机制。
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