Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, PR China.
Hull York Medical School, University of Hull, Heslington, YO10 5DD, UK.
Biomark Med. 2019 Nov;13(16):1363-1372. doi: 10.2217/bmm-2018-0476. Epub 2019 Oct 10.
We aimed to explore gender impacts on the associations between red blood cell distribution width (RDW) and thyroid function in the Chinese population. Gender impacts on the associations between RDW and thyroid function in 8424 males and 5198 females were investigated. RDW was found significantly lower in males than in females. An increasing trend of RDW along with aging was demonstrated in males. For females, an obvious decrease was shown during menopause period. From binary logistic regression, RDW displayed negative relationship with hypothyroidism in both genders as a single factor. However, if RDW was analyzed as a categorical variable (in RDW width quartiles) and as a continuous variable in models with covariates, all the odds ratios were negative, except for a weak-negative relationship with hypothyroidism in women in a continuous RDW model. The current study suggests that anisocytosis could be a contributing factor in thyroid dysfunction.
我们旨在探讨性别对红细胞分布宽度（RDW）与甲状腺功能在中国人群中的相关性的影响。 我们调查了性别对 8424 名男性和 5198 名女性的 RDW 与甲状腺功能之间相关性的影响。 结果发现，男性的 RDW 明显低于女性。 男性的 RDW 随年龄增长呈上升趋势。 对于女性，在绝经期期间显示出明显的下降。 从二元逻辑回归来看，RDW 作为单一因素显示出与两种性别中的甲状腺功能减退之间的负相关关系。 然而，如果将 RDW 作为分类变量（在 RDW 宽度四分位数中）以及在具有协变量的模型中作为连续变量进行分析，则所有的比值比均为负，除了在连续 RDW 模型中女性与甲状腺功能减退的弱负相关关系。 本研究表明，不均一性可能是甲状腺功能障碍的一个促成因素。
