miR-21、miR-146b 和 miR-326 的表达水平作为白塞病的潜在生物标志物。
Expression levels of miR-21, miR-146b and miR-326 as potential biomarkers in Behcet's disease.
机构信息
Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Internal Medicine, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Biomark Med. 2019 Nov;13(16):1339-1348. doi: 10.2217/bmm-2019-0098. Epub 2019 Oct 10.
Behcet's disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD.
贝赫切特病（BD）是一种血管炎。有证据表明，miRNA 可作为自身免疫性疾病的诊断和预后标志物。本研究旨在探讨 miR-21、miR-146b 和 miR-326 作为诊断、预测器官受累和衡量 BD 活动的生物标志物的潜在作用。在这项横断面研究中，研究组包括 46 名 BD 患者和 70 名年龄和性别匹配的健康志愿者。通过定量实时 PCR 测定了三种 miRNA 的表达率。我们的研究结果表明，BD 患者的 miR-21 和 miR-146b 表达水平显著降低，miR-326 表达水平升高。严重眼部受累患者的 miR-21 表达率和葡萄膜炎及严重眼部受累患者的 miR-326 表达率增加。miR-326 表达率可作为预测 BD 患者葡萄膜炎和严重眼部受累的生物标志物。
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