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接受微创子宫肌瘤切除术的女性围手术期阿片类药物趋势。

Perioperative Narcotic Trends in Women Undergoing Minimally Invasive Myomectomy.

机构信息

Department of Obstetrics and Gynecology, Division of Minimally Invasive Gynecology, University of North Carolina, Chapel Hill, North Carolina (Dr. Tyan).

Departments of Obstetrics and Gynecology (Drs. Klebanoff and Moawad) and Surgery (Dr. Amdur), The George Washington University Hospital, Washington, District of Columbia.

出版信息

J Minim Invasive Gynecol. 2020 Sep-Oct;27(6):1383-1388.e1. doi: 10.1016/j.jmig.2019.09.787. Epub 2019 Oct 7.

Abstract

STUDY OBJECTIVE

Evaluate the perioperative narcotic utilization patterns at the time of myomectomy, specifically as they relate to the opioid epidemic. We also aim to evaluate the differences between conventional laparoscopy and robotic surgery in terms of narcotic utilization.

DESIGN

Retrospective cohort study.

SETTING

Single academic university hospital.

PATIENTS

Women undergoing minimally invasive myomectomy.

INTERVENTIONS

Laparoscopic or robot-assisted myomectomy.

MEASUREMENTS AND MAIN RESULTS

We identified 312 minimally invasive myomectomies to be included in the final analysis. For the entire cohort, the mean age (± standard deviation) was 35.7 ± 5.1 years, and the mean body mass index was 28.3 ± 6.3. Of the 312 myomectomies included, 239 (76.6%) were performed using robotic assistance, and the remainder (23.4%) were performed by conventional laparoscopy. A statistically significant inverse relationship was found between year of myomectomy and perioperative narcotic administration (p <.001). Yearly morphine milligram equivalent (MME) administration decreased significantly for both intraoperative and postoperative administration (p <.001). The largest decline for intraoperative MME use was between 2016 and 2017, and for postoperative MME use, it was between 2012 and 2013. There was no statistically significant difference in perioperative narcotic administration between conventional laparoscopy and robot-assisted myomectomy. The time effect for intraoperative (p <.001) and postoperative (p <.001) narcotic administration remained significant after adjusting for covariates, including mode of surgery, race, insurance, age, and body mass index. None of the background variables assessed were associated with perioperative narcotic administration.

CONCLUSION

Perioperative narcotic administration for minimally invasive myomectomy has decreased following widespread awareness of the national opioid crisis.

摘要

研究目的

评估子宫肌瘤剔除术围手术期的麻醉药物使用模式,特别是与阿片类药物流行相关的模式。我们还旨在评估传统腹腔镜手术和机器人手术在麻醉药物使用方面的差异。

设计

回顾性队列研究。

地点

单家学术型大学医院。

患者

接受微创子宫肌瘤剔除术的女性。

干预措施

腹腔镜或机器人辅助子宫肌瘤剔除术。

测量和主要结果

我们确定了 312 例微创子宫肌瘤剔除术纳入最终分析。对于整个队列,平均年龄(±标准差)为 35.7±5.1 岁,平均体重指数为 28.3±6.3。在纳入的 312 例子宫肌瘤剔除术中,239 例(76.6%)采用机器人辅助完成,其余 23.4%采用传统腹腔镜完成。子宫肌瘤剔除术年份与围手术期麻醉药物使用呈显著负相关(p<.001)。术中及术后吗啡毫克当量(MME)给药量均显著减少(p<.001)。术中 MME 使用量最大的下降发生在 2016 年至 2017 年之间,术后 MME 使用量最大的下降发生在 2012 年至 2013 年之间。传统腹腔镜与机器人辅助子宫肌瘤剔除术在围手术期麻醉药物使用方面无统计学差异。在校正手术方式、种族、保险、年龄和体重指数等混杂因素后,术中(p<.001)和术后(p<.001)麻醉药物使用的时间效应仍然显著。评估的背景变量均与围手术期麻醉药物使用无关。

结论

在全国阿片类药物危机意识普遍提高的情况下,微创子宫肌瘤剔除术的围手术期麻醉药物使用量有所减少。

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