长链非编码 RNA AB209371 通过下调 miR-203 上调卵巢癌细胞中的 Survivin 基因。
LncRNA AB209371 up-regulated Survivin gene by down-regulating miR-203 in ovarian carcinoma.
机构信息
State Key Laboratory Cultivation Base For TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.
Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science; College of Health Sciences, Jiangsu Normal University, No. 101, Shanghai Road, Tongshan District, Xuzhou, 221116, Jiangsu Province, People's Republic of China.
出版信息
J Ovarian Res. 2019 Oct 10;12(1):92. doi: 10.1186/s13048-019-0559-4.
AB209371 gene has been characterized as an oncogenic lncRNA in liver cancer. However, its involvement in ovarian carcinoma (OC) is unknown. In the present study, we analyzed the roles of AB209371 in OC. We found that AB209371 gene and Survivin gene were up-regulated in OC and positively correlated with OC development. AB209371 over-expression led to up-regulated Survivin in OC cells, while Survivin over-expression failed to affect AB209371. In addition, AB209371 over-expression led to down-regulated miR-203. However, miR-203 over-expression failed to affect AB209371, but down-regulated the expression of Survivin. In addition, over-expressions of AB209371 and Survivin resulted in the increased proliferation rate of OC cells. Over-expression MiR-203 played the opposite role and attenuated the effects of AB209371 over-expression. Therefore, AB209371 may down-regulate miR-203 to up-regulate Survivin, thereby promoting OC cell proliferation. Our study provided novel insights into the pathogenesis of OC.
AB209371 基因已被证实为肝癌中的致癌 lncRNA。然而，其在卵巢癌（OC）中的作用尚不清楚。在本研究中，我们分析了 AB209371 在 OC 中的作用。我们发现，AB209371 基因和 Survivin 基因在 OC 中上调，并与 OC 的发生发展呈正相关。AB209371 的过表达导致 OC 细胞中 Survivin 的上调，而 Survivin 的过表达则未能影响 AB209371。此外，AB209371 的过表达导致 miR-203 的下调。然而，miR-203 的过表达未能影响 AB209371，但下调了 Survivin 的表达。此外，AB209371 和 Survivin 的过表达导致 OC 细胞增殖率增加。过表达 miR-203 则起到相反的作用，减弱了 AB209371 过表达的作用。因此，AB209371 可能通过下调 miR-203 来上调 Survivin，从而促进 OC 细胞的增殖。本研究为 OC 的发病机制提供了新的见解。
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