Dundee J W, Halliday N J, Loughran P G, Harper K W
Anaesthesia. 1985 May;40(5):441-3. doi: 10.1111/j.1365-2044.1985.tb10845.x.
There was a considerable individual variation in response to a standard induction dose of 0.3 mg/kg midazolam in unpremedicated patients. This is shown by variations in time to onset of sleep and the fact that about one quarter of subjects did not lose consciousness in 3 minutes. In 166 fit patients a good negative correlation was demonstrated between the age of the patients and time to loss of consciousness. Patients over 50 years differed from younger patients in a greater reliability of effect and significantly shorter induction time. In elderly patients midazolam is a more reliable induction agent than in the young.
在未使用术前药的患者中，给予0.3mg/kg咪达唑仑标准诱导剂量后，个体反应存在相当大的差异。这表现为入睡时间的变化，以及约四分之一的受试者在3分钟内未失去意识。在166例健康患者中，患者年龄与意识消失时间之间呈现出良好的负相关。50岁以上的患者与年轻患者不同，其效果更可靠，诱导时间明显更短。在老年患者中，咪达唑仑作为诱导药物比在年轻患者中更可靠。
