Reves J G, Newfield P, Smith L R
Can Anaesth Soc J. 1981 Nov;28(6):556-60. doi: 10.1007/BF03007152.
Individual variation occurs in time to induction of anaesthesia with intravenous drugs. Less free drug is available to cross the blood-brain barrier when the drug is highly protein bound. Since this may prolong time to sleep, we correlated the induction time, serum albumin and total protein concentrations, and doses of midazolam, which is a highly protein bound intravenous anaesthetic. There is a poor correlation (r = 0.062) between induction time and serum protein, a weak (r = 0.542) but statistically significant (p = 0.026) correlation between induction time and serum albumin, and a highly significant (p = 0.003) negative correlation (r = 0.579) between drug dose and induction time. The administration of the appropriate dose of midazolam for induction, therefore, appears to affect induction time more significantly than does the serum albumin concentration.
使用静脉药物诱导麻醉的时间存在个体差异。当药物与蛋白质高度结合时，可用于穿过血脑屏障的游离药物较少。由于这可能会延长入睡时间，我们对诱导时间、血清白蛋白和总蛋白浓度以及咪达唑仑（一种与蛋白质高度结合的静脉麻醉剂）的剂量进行了相关性分析。诱导时间与血清蛋白之间的相关性较差（r = 0.062），诱导时间与血清白蛋白之间存在较弱（r = 0.542）但具有统计学意义（p = 0.026）的相关性，药物剂量与诱导时间之间存在高度显著（p = 0.003）的负相关（r = 0.579）。因此，诱导时给予适当剂量的咪达唑仑似乎比血清白蛋白浓度对诱导时间的影响更大。
