Baber R, Hobbes A, Munro I A, Purcell G, Binstead R
Anaesth Intensive Care. 1982 Feb;10(1):29-35. doi: 10.1177/0310057X8201000107.
The peripheral and central nervous, cardiovascular and respiratory effects of midazolam 0.15 mg/kg, administered intravenously, were studied in 57 patients. Midazolam induced anaesthesia satisfactorily in 78% of the patients, the remainder required either further doses of midazolam, or alternative induction agents. There was no pain on injection. No evidence of thrombophlebitis was apparent up to 72 hours after injection. Mean systolic arterial pressure decreased from 128 mm Hg to 114 mm Hg and mean diastolic pressure decreased from 75 mm Hg to 67 mm Hg (P less than 0.005) four minutes after injection. Mean Apnoea occurred in 14 patients, with a mean onset time of 82 sec and a mean duration of 30 sec. Patients showed a decrease in mean respiratory rate from 13.7 breaths/min to 12.8 breaths/min two minutes after injection of midazolam. A larger dose than used in this study would be necessary for satisfactory use of midazolam as an induction agent for general anaesthesia.
对57例患者静脉注射0.15mg/kg咪达唑仑后的外周和中枢神经、心血管及呼吸效应进行了研究。78%的患者使用咪达唑仑诱导麻醉效果满意，其余患者需要追加咪达唑仑剂量或使用其他诱导药物。注射时无疼痛。注射后72小时内未发现明显的血栓性静脉炎迹象。注射后4分钟，平均收缩压从128mmHg降至114mmHg，平均舒张压从75mmHg降至67mmHg（P<0.005）。14例患者出现平均呼吸暂停，平均发作时间为82秒，平均持续时间为30秒。注射咪达唑仑两分钟后，患者的平均呼吸频率从13.7次/分钟降至12.8次/分钟。要使咪达唑仑作为全身麻醉诱导药物得到满意使用，需要比本研究中使用的剂量更大。
