Wencheng Dang-Zhi, Geri Duo-Jie, Qieni Xiang-Mao, Cairang Ji, Gongbao Dong-Zhi, Donggai Cuo, Song Xin-Chen, Zhang Yi, DE Luo
Ethnic Medicine School,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China Mongolia and Tibetan Medicine Hospital in Doulan County Delingha 816100,China.
Tibetan Medical College,Qinghai University Xining 810016,China.
Zhongguo Zhong Yao Za Zhi. 2019 Aug;44(15):3143-3150. doi: 10.19540/j.cnki.cjcmm.20190628.207.
This study aimed to explore the rule of Tibetan medicine in clinical treatment of hypertension( k Hrag-rLung-stod-vtshangs) and analyze the characteristics of its prescriptions. One hundred and thirty-seven cases of hypertension treated Tibetan medicine were collected. Data mining,Gephi,Cytoscape and other methods and software were used to analyze the characteristics of Tibetan medicine. The results showed that there were 44 cases of r Lung-type hypertension in clinical medical records,while 57 cases of k Hrag-type hypertension. There were 103 treatment prescriptions. The frequency of these prescriptions covered Twenty-five Yuganzi Pills( 96 times),Seventy Pearl Pills( 80 times),Eight Chenxiang Pills( 75 times),and Sanwei Ganlu Powder( 62 times),and they were highly correlated,with confidence greater than 95%. There were 332 prescriptions involved in the prescriptions which is core prescription medicines. This study first proposed the dosage analysis method of Tibetan medicine prescription medicines,and obtained the more dosage of Chebulae Fructus,Phyllanthi Fructus,Aucklandiae Radix,Aquilariae Lignum Resinatum and so on. The correlation analysis of the prescription medicines found that Carthami Flos,Myristicae Semen,Bambusae Concretio Silicea,Caryophylli Flos,Amomi Fructus Rotundus led by Tsaoko Fructus had a high correlation and a confidence greater than 75%. These herbs were guaranteed when Tibetan medicine was used in combination. The key drugs for protecting viscera and regulating the three gastric fires. The prescription is mainly cold,blunt,sparse and rough. Its efficacy focuses on the pathogenesis of blood fever,blood stickiness and venous blockage caused by heat,sharpness,odor and stickiness. It mainly treats Tibetan medicine diseases such as k Hrag-r Lung-stod-vtshangs and k Hrag-vpel( polyemia). It is suggested that Tibetan medicine has a three-in-one invisible treatment principle of " clearing blood-heat,opening vessel and regulating stomach-fire" in the treatment of hypertension,which attributed to both cardiovascular function and gastrointestinal metabolic function. This may be a significant and invisible knowledge of Tibetan medicine in the treatment of hypertension.
本研究旨在探讨藏医治疗高血压（隆赤巴协日）的临床用药规律，并分析其方剂特点。收集137例接受藏医治疗的高血压患者病例。运用数据挖掘、Gephi、Cytoscape等方法及软件对藏医用药特点进行分析。结果显示，临床病历中隆型高血压44例，赤型高血压57例。共有103个治疗方剂。这些方剂的用药频次涵盖二十五味余甘子丸（96次）、七十味珍珠丸（80次）、八味沉香丸（75次）、三味甘露散（62次），且它们相关性较高，置信度大于95%。核心处方药物涉及的方剂有332个。本研究首次提出藏医方剂药物用量分析方法，得出诃子、余甘子、木香、沉香等用量较多。对方剂药物进行相关性分析发现，以草果为主导的红花、肉豆蔻、竹黄、丁香、砂仁相关性较高，置信度大于75%。这些药物在藏医组方配伍时具有保障作用。是护脏器、调三胃火的关键药物。方剂以寒凉、钝、糙、稀为主。其功效着重于因热、锐、臭、黏导致的血热、血黏、脉络阻滞的病机。主要治疗隆赤巴协日、赤巴偏盛（多血症）等藏医病症。提示藏医在治疗高血压方面具有“清热、通络、调胃火”三位一体的无形治疗原则，这与心血管功能和胃肠代谢功能均有关。这可能是藏医在治疗高血压方面重要且无形的知识。
