Key Laboratory of Molecular Medicine and Biotherapy, School of Life Sciences , Beijing Institute of Technology , Beijing 100811 , P. R. China.
School of Science, Westlake Institute for Advanced Study , Westlake University , 18 Shilongshan Road , Hangzhou 310024 , P. R. China.
ACS Appl Mater Interfaces. 2019 Nov 6;11(44):41051-41061. doi: 10.1021/acsami.9b14552. Epub 2019 Oct 23.
A recent breakthrough in the discovery of thermally activated delayed fluorescence (TADF) emitters characterized by small single-triplet energy offsets (Δ) offers a wealth of new opportunities to exploit high-performance metal-free photosensitizers. In this report, two intrinsically cancer-mitochondria-targeted TADF emitters-based nanoparticles (TADF NPs) have been developed for two-photon-activated photodynamic therapy (PDT) and fluorescence imaging. The as-prepared TADF NPs integrate the merits of (1) high O quantum yield of 52%, (2) sufficient near-infrared light penetration depth due to two-photon activation, and (3) excellent structure-inherent mitochondria-targeting capabilities without extra chemical or physical modifications, inducing remarkable endogenous mitochondria-specific reactive oxygen species production and excellent cancer-cell-killing ability at an ultralow light irradiance. We believe that the development of such intrinsically multifunctional TADF NPs stemming from a single molecule will provide new insights into exploration of novel PDT agents with strong photosensitizing ability for various biomedical applications.
最近在热激活延迟荧光（TADF）发射器的发现方面取得了突破，其特点是单三重态能量差（Δ）较小，这为开发高性能无金属光敏剂提供了丰富的新机会。在本报告中，我们开发了两种基于内在的癌症-线粒体靶向 TADF 发射器的纳米粒子（TADF NPs），用于双光子激活光动力疗法（PDT）和荧光成像。所制备的 TADF NPs 集成了以下优点：（1）高 O 量子产率为 52%；（2）由于双光子激活，具有足够的近红外光穿透深度；（3）具有出色的结构固有线粒体靶向能力，无需额外的化学或物理修饰，可诱导显著的内源性线粒体特异性活性氧物质产生，并在超低光辐照度下具有优异的癌细胞杀伤能力。我们相信，这种源自单个分子的内在多功能 TADF NPs 的开发将为探索具有强光敏能力的新型 PDT 剂提供新的思路，可应用于各种生物医学领域。
