Institutes of Physics Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Ministry of Education, Anhui University, Hefei, 230601, People's Republic of China.
Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei, 230601, People's Republic of China.
J Nanobiotechnology. 2022 May 6;20(1):217. doi: 10.1186/s12951-022-01436-3.
Designing new oxygenation nanomaterials by oxygen-generating or oxygen-carrying strategies in hypoxia-associated anti-tumor therapy is a high priority target yet challenge. In this work, we fabricated a nanoplatform involving Fenton-like reaction, Pd@MOF-525@HA, to relieve tumor hypoxia via oxygen-generating strategy for enhanced oxygen-dependent anti-tumor therapy. Thereinto, the porphyrinic MOF-525 can produce singlet oxygen (O) via light or ultrasonic irradiation for photodynamic and sonodynamic therapy. Notably, the well-dispersed Pd nanocubes within MOF-525 can convert HO into O to mitigate the hypoxic environment for enhanced therapy outcome. Moreover, the two-photon activity and cancer cell specific targeting capability of Pd@MOF-525@HA gave rise to deeper tissue penetration and near-infrared light-induced fluorescence imaging to achieve precise guidance for cancer therapy. This work provides a feasible way in designing new oxygenation nanomaterials to relieve tumor hypoxia for enhanced cancer treatment.
通过产氧或携氧策略设计新的氧合纳米材料，用于缺氧相关的抗肿瘤治疗，是一个高度优先的目标，但也是一个挑战。在这项工作中，我们构建了一个包含芬顿样反应的纳米平台，即 Pd@MOF-525@HA，通过产氧策略来缓解肿瘤缺氧，以增强依赖氧的抗肿瘤治疗。其中，卟啉 MOF-525 可以通过光或超声辐射产生单线态氧（O），用于光动力和超声动力治疗。值得注意的是，分散良好的 MOF-525 内的 Pd 纳米立方体能将 HO 转化为 O，以减轻缺氧环境，从而提高治疗效果。此外，Pd@MOF-525@HA 的双光子活性和癌细胞特异性靶向能力，使得其能够更深地穿透组织，并实现近红外光诱导荧光成像，从而实现对癌症治疗的精确指导。这项工作为设计新的氧合纳米材料以缓解肿瘤缺氧、增强癌症治疗提供了一种可行的方法。
