Primary Care Sports Medicine Fellowship, Department of Family & Community Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina.
Bozeman Health Family Medicine at Belgrade Clinic, Belgrade, Montana.
Sports Health. 2020 Mar/Apr;12(2):149-153. doi: 10.1177/1941738119877177. Epub 2019 Oct 11.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is likely the most prevalent enzyme deficiency on the planet, with an estimated 4.9% of people, or approximately 330 million individuals, across the globe affected by the disease. In the United States, 4% to 7% of the population is likely affected, but each year our nation's major sport leagues become more international. It is important for medical professionals who treat athletes to understand how this genetic condition can affect the athletes we are working with, especially because exercise in itself results in oxidative stress.
PubMed was searched for relevant articles published from 1980 to 2018. The search terms , , , and were used.
Clinical review.
Level 4.
Though some case reports suggest a potential impact on athlete safety and performance, controlled studies demonstrate limited impact of exercise on oxidative stress in G6PD-deficient individuals. The care of athletes with G6PD deficiency does not drastically differ from the care of athletes without this condition. Most of the medications and supplements that are regularly given to athletes should not negatively affect their health.
Although the care of athletes with G6PD deficiency is for the most part no different from the care of other athletes, there are certain situations (visiting areas where malaria is endemic) and medications for which it is important to recognize how your management should change. G6PD deficiency is not regularly screened for but could be considered if an athlete has known sickle cell disease or when traveling to areas where malaria is prevalent. Expanding our knowledge of G6PD deficiency will allow for better care of athletes.
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症可能是地球上最常见的酶缺乏症，全球约有 4.9%的人，即约 3.3 亿人患有这种疾病。在美国，可能有 4%至 7%的人口受到影响，但每年美国的主要体育联盟都变得更加国际化。对于治疗运动员的医疗专业人员来说，了解这种遗传状况如何影响他们正在合作的运动员是很重要的，特别是因为运动本身会导致氧化应激。
从 1980 年到 2018 年，在 PubMed 上搜索了发表的相关文章。使用了以下搜索词：、、、。
临床综述。
4 级。
尽管一些病例报告表明这对运动员的安全和表现可能有潜在影响，但对照研究表明，运动对 G6PD 缺乏个体的氧化应激影响有限。患有 G6PD 缺乏症的运动员的护理与没有这种情况的运动员的护理没有明显区别。大多数经常给予运动员的药物和补充剂不应对其健康产生负面影响。
尽管患有 G6PD 缺乏症的运动员的护理在大多数情况下与其他运动员的护理没有区别，但在某些情况下（前往疟疾流行地区）和某些药物治疗中，重要的是要认识到如何改变您的管理方法。G6PD 缺乏症通常不会进行筛查，但如果运动员已知患有镰状细胞病或前往疟疾流行地区旅行时，可能会考虑进行筛查。扩大对 G6PD 缺乏症的认识将有助于更好地治疗运动员。
