Das Susanta Kumar, Jana Debarshi, Ghosh Bastab, Pal Dilip Kumar
Department of Urology, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Turk J Urol. 2019 Nov 1;45(6):431-436. doi: 10.5152/tud.2019.49354. Print 2019 Nov.
This study is a randomized controlled study comparing the effectiveness and outcomes of direct visual inter urethrotomy (DVIU) for short segment anterior urethral strictures performed under local anesthesia versus spinal anesthesia.
Patients presenting with an anterior urethral stricture up to 2 cm were randomized into two interventional groups: Group I-DVIU done under spinal anesthesia and Group II-DVIU performed under local anesthesia. Procedural discomfort was analyzed with a visual analog scale (VAS) immediately postoperatively and after one hour of the procedure. The changes in the vital parameters (systolic blood pressure and pulse rate) were recorded. The success of the procedure was defined as the absence of symptoms of recurrent stricture along with the ability of self-urethral calibration with an 18Fr catheter on follow-up.
One hundred and twenty patients, between December 2015 and February 2017, were randomized into the two above-mentioned groups with 60 patients each. The demographic profile, the stricture characteristics (etiology, length, and duration of symptoms), and the preoperative parameters (Q, preoperative pulse rate, and systolic blood pressures) were comparable in both the groups. The mean (±SD) intraoperative and one-hour postoperative VAS scores were 1.96 (±1.04) and 1.20 (±0.73), respectively, for Group I, which were significantly less (p<0.05) than the VAS scores 4.26 (± 1.98) and 2.13 (±1.71), respectively, for Group II. The intraoperative mean increases in pulse rate and systolic blood pressure were also significantly lower in Group I (p<0.05). The change in postoperative Q (mL/sec) was comparable in both the groups (mean of 20.75±4.31 vs. 19.041 4.88) and so is the stricture free rate at a one-year follow-up. No significant differences in complication rates were observed in both the groups.
Although perioperative procedural parameters seem to be in favor of spinal anesthesia, the outcome of DVIU is independent of the type of anesthesia used.
本研究是一项随机对照研究,比较局部麻醉与脊髓麻醉下行直视尿道内切开术(DVIU)治疗短段前尿道狭窄的有效性和结果。
将前尿道狭窄长度达2 cm的患者随机分为两个干预组:第一组在脊髓麻醉下行DVIU,第二组在局部麻醉下行DVIU。术后立即及术后1小时用视觉模拟量表(VAS)分析手术不适情况。记录生命体征参数(收缩压和脉搏率)的变化。手术成功定义为随访时无复发性狭窄症状且能用18Fr导管自行尿道扩张。
2015年12月至2017年2月期间,120例患者被随机分为上述两组,每组60例。两组患者的人口统计学特征、狭窄特征(病因、长度和症状持续时间)以及术前参数(Q、术前脉搏率和收缩压)具有可比性。第一组术中及术后1小时的平均(±标准差)VAS评分分别为1.96(±1.04)和1.20(±0.73),显著低于第二组的VAS评分4.26(±1.98)和2.13(±1.71)(p<0.05)。第一组术中脉搏率和收缩压的平均升高也显著较低(p<0.05)。两组术后Q(mL/秒)的变化具有可比性(平均值分别为20.75±4.31和19.04±4.88),一年随访时的无狭窄率也是如此。两组并发症发生率无显著差异。
虽然围手术期手术参数似乎有利于脊髓麻醉,但DVIU的结果与所用麻醉类型无关。