Al-Kuraishy Hayder M, Al-Gareeb Ali Ismail, Hussien Nawar Raad, Al-Naimi Marwa Salih, Rasheed Huda Abdulbaki
Department of Clinical Pharmacology, Medicine and Therapeutic, Al-Mustansiriya University, Baghdad, Iraq.
Department of Clinical Pharmacology, Medicine and Therapeutic, Al- Mustansiriya University, Baghdad, Iraq.
J Pak Med Assoc. 2019 Aug;69(Suppl 3)(8):S108-S112.
Statins are hydroxymethylglutaryl-coenzyme A reductase inhibitors inhibit denovo cholesterol synthesis leading to reduction of serum cholesterol and low density lipoprotein as well as elevation of high density lipoprotein level. Statins are used in the treatment of dyslipidaemia, prevention of major cardiovascular events and complications. The potential role of statins in the induction of peripheral neuropathy has not been verified as most of statins induced-peripheral neuropathy had been reported as case reports. Also, statins therapy leads to noteworthy reduction of Coenzyme Q10, causing impairment of neuronal energy. The incidence of polyneuropathy was high with atorvastatin (65%) which is lipophilic, and relatively less with fluvastatin (54%) which is hydrophilic. Long-term statins therapy, mainly with atorvastatin and simvastatin, is linked with thedevelopment of peripheral neuropathy.
他汀类药物是羟甲基戊二酰辅酶A还原酶抑制剂，可抑制胆固醇从头合成，从而降低血清胆固醇和低密度脂蛋白水平，并提高高密度脂蛋白水平。他汀类药物用于治疗血脂异常、预防主要心血管事件和并发症。他汀类药物诱发周围神经病变的潜在作用尚未得到证实，因为大多数他汀类药物诱发周围神经病变的报道都是病例报告。此外，他汀类药物治疗会导致辅酶Q10显著减少，从而损害神经元能量。亲脂性的阿托伐他汀导致多发性神经病变的发生率较高（65%），而亲水性的氟伐他汀导致的发生率相对较低（54%）。长期使用他汀类药物治疗，主要是阿托伐他汀和辛伐他汀，与周围神经病变的发生有关。
