Ziajka P E, Wehmeier T
Florida Lipid Associates, Orlando 32806, USA.
South Med J. 1998 Jul;91(7):667-8. doi: 10.1097/00007611-199807000-00013.
We report a case of a peripheral neuropathy induced and exacerbated by several commonly used HMG-CoA reductase inhibitors including lovastatin, simvastatin, pravastatin, and atorvastatin, and the vitamin niacin. A review of the literature shows similar cases with individual lipid-lowering drugs, but this case shows the cross-reactivity of the neuropathic process to different HMG-CoA reductase inhibitors, and it is the first reported case of a peripheral neuropathy exacerbated by the use of niacin.
我们报告了一例由几种常用的HMG-CoA还原酶抑制剂（包括洛伐他汀、辛伐他汀、普伐他汀和阿托伐他汀）以及维生素烟酸引起并加重的周围神经病变。文献回顾显示了个别降脂药物导致的类似病例，但本病例显示了神经病变过程对不同HMG-CoA还原酶抑制剂的交叉反应，并且这是首例因使用烟酸而加重周围神经病变的报告病例。
