Alruwaili Nahi Sabih, Al-Kuraishy Hayder M, Al-Gareeb Ali I, Albuhadily Ali K, Ragab Amany E, Alenazi Ahmad Awad, Alexiou Athanasios, Papadakis Marios, Batiha Gaber El-Saber
Eradah Complex of Mental Health -Northern Border Region, Ministry of Health, Al Bahah, Saudi Arabia.
Department of Clinical pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
Diabetol Metab Syndr. 2023 Aug 31;15(1):179. doi: 10.1186/s13098-023-01149-z.
Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates the progression of depression in T2D patients. Therefore, management of depression by antidepressant agents improves glucose homeostasis and insulin sensitivity. However, prolong use of antidepressant drugs may increase the risk for the development of T2D. However, there is strong controversy concerning the use of antidepressant drugs in T2D. Therefore, this review try to elucidate the potential effects of antidepressant drugs in T2D regarding their detrimental and beneficial effects.
2型糖尿病（T2D）是一种由胰岛素抵抗（IR）、相对胰岛素缺乏和高血糖发展引起的代谢性疾病。高血糖诱导的神经化学失调会激活T2D患者抑郁症的进展。因此，使用抗抑郁药治疗抑郁症可改善葡萄糖稳态和胰岛素敏感性。然而，长期使用抗抑郁药可能会增加患T2D的风险。然而，关于在T2D中使用抗抑郁药存在很大争议。因此，本综述试图阐明抗抑郁药在T2D中关于其有害和有益作用的潜在影响。
