Faculty of Veterinary Medicine, Department of Medicine and Infectious Diseases, Cairo University, Giza, Egypt.
Faculty of Veterinary Medicine, Department of Medicine and Infectious Diseases, Cairo University, Giza, Egypt.
Virus Res. 2019 Dec;274:197774. doi: 10.1016/j.virusres.2019.197774. Epub 2019 Oct 10.
Peste des petits ruminants (PPR) is an acute transboundary infectious viral disease affecting domestic and wild small ruminants' species besides camels reared in Africa, Asia and the Middle East. The virus is a serious paramount challenge to the sustainable agriculture advancement in the developing world. The disease outbreak was also detected for the first time in the European Union namely in Bulgaria at 2018. Therefore, the disease has lately been aimed for eradication with the purpose of worldwide clearance by 2030. Radically, the vaccines needed for effectively accomplishing this aim are presently convenient; however, the availableness of innovative modern vaccines to fulfill the desideratum for Differentiating between Infected and Vaccinated Animals (DIVA) may mitigate time spent and financial disbursement of serological monitoring and surveillance in the advanced levels for any disease obliteration campaign. We here highlight what is at the present time well-known about the virus and the different available diagnostic tools. Further, we interject on current updates and insights on several novel vaccines and on the possible current and prospective strategies to be applied for disease control.
小反刍兽疫（PPR）是一种急性跨境传染病，除了在非洲、亚洲和中东饲养的骆驼外，还会影响到家养和野生小反刍动物物种。该病毒是发展中国家可持续农业发展的一个严重的首要挑战。该疾病的爆发也首次在欧盟即保加利亚 2018 年被发现。因此，最近的目标是消灭这种疾病，目的是在 2030 年实现全球清除。从根本上说，目前有有效的疫苗来实现这一目标，但为了满足区分感染动物和接种疫苗动物（DIVA）的要求，需要有创新的现代疫苗，这可能会减少在任何疾病消除运动中进行血清学监测和监测的时间和财政支出。我们在这里强调了目前人们对该病毒的了解，以及不同的现有诊断工具。此外，我们还介绍了几种新型疫苗的最新情况和见解，以及可能应用于疾病控制的当前和未来策略。
