Batton Emily, Alali Muayad, Hageman Joseph R, Parilla Megan, Yu Karl O A
Pediatr Ann. 2019 Oct 1;48(10):e406-e411. doi: 10.3928/19382359-20190920-01.
Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare, benign, and self-limited disease that causes lymphadenopathy and has a characteristic histological appearance. The etiology of this disease is unknown, but a possible infectious trigger has been hypothesized. In the adult population this disease is more common in females; however, in the pediatric population it is more common in males. Descriptions in the pediatric literature are lacking, particularly in the United States. The authors report three cases of pediatric KFD that presented at the same institution in a 9-month time period. All three patients were male and of non-Asian descent who were diagnosed with KFD by histopathologic specimen after presenting with unilateral cervical lymphadenitis. Each patient had additional laboratory evidence of a possible bacterial infection at the time of diagnosis. These three cases highlight the importance of considering KFD early when a pediatric patient presents with unilateral cervical lymphadenitis. The authors discuss the epidemiology, etiology, clinical manifestations, diagnostic approaches, and treatment of KFD. [Pediatr Ann. 2019;48(10):e406-e411.].
菊池-藤本病（KFD），即组织细胞性坏死性淋巴结炎，是一种罕见的、良性的、自限性疾病，可导致淋巴结病，具有特征性组织学表现。本病病因不明，但推测可能有感染诱因。在成人中，本病女性更为常见；然而，在儿童中，男性更为常见。儿科文献中对此病的描述较少，尤其是在美国。作者报告了在9个月内于同一机构就诊的3例儿童KFD病例。所有3例患者均为非亚裔男性，在出现单侧颈淋巴结炎后经组织病理学标本诊断为KFD。每位患者在诊断时均有其他可能存在细菌感染的实验室证据。这3例病例凸显了儿科患者出现单侧颈淋巴结炎时早期考虑KFD的重要性。作者讨论了KFD的流行病学、病因、临床表现、诊断方法及治疗。[《儿科年鉴》。2019年；48（10）：e406-e411。]
