Lee Chih-Hung, Cheng Shih-Tsung
Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2003 May;19(5):246-51. doi: 10.1016/S1607-551X(09)70432-2.
We describe a rare but typical case of Kikuchi-Fujimoto disease (KFD). Two subcutaneous nodules appeared suddenly on the right of the neck of a 15-year-old girl. Microscopy of a surgical specimen of the larger nodule showed necrotizing lymphadenitis. Prompt treatment with mepirizole resulted in the disappearance of the smaller nodule. No recurrence was noted during 6 months of follow-up. KFD is a rare, self-limiting, necrotizing histiocytic lymphadenitis that needs to be differentiated from malignant lymphoma. Any nodal biopsy showing fragmented nuclei, necrosis, and karyorrhexis without prominent neutrophils should alert the physician to consideration of KFD, especially in a young woman presenting with cervical lymphadenopathy.
我们描述了一例罕见但典型的菊池-藤本病（KFD）。一名15岁女孩颈部右侧突然出现两个皮下结节。对较大结节的手术标本进行显微镜检查显示为坏死性淋巴结炎。使用美吡立唑迅速治疗后，较小的结节消失。随访6个月期间未观察到复发。KFD是一种罕见的、自限性的坏死性组织细胞性淋巴结炎，需要与恶性淋巴瘤相鉴别。任何显示细胞核破碎、坏死和核溶解且无明显中性粒细胞的淋巴结活检，都应提醒医生考虑KFD，尤其是在出现颈部淋巴结病的年轻女性中。
