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交变磁场中磁性铁蛋白纳米颗粒加热效率的实验评估

Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field.

作者信息

Xu Huangtao, Pan Yongxin

机构信息

Biogeomagnetism Group, Paleomagnetism and Geochronology Laboratory, Key Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China.

Institutions Earth Science, Chinese Academy of Sciences, Beijing 100029, China.

出版信息

Nanomaterials (Basel). 2019 Oct 14;9(10):1457. doi: 10.3390/nano9101457.

DOI:10.3390/nano9101457
PMID:31615049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6835341/
Abstract

The superparamagnetic substance magnetoferritin is a potential bio-nanomaterial for tumor magnetic hyperthermia because of its active tumor-targeting outer protein shell, uniform and tunable nanosized inner mineral core, monodispersity and good biocompatibility. Here, we evaluated the heating efficiency of magnetoferritin nanoparticles in an alternating magnetic field (AMF). The effects of core-size, Fe concentration, viscosity, and field frequency and amplitude were investigated. Under 805.5 kHz and 19.5 kA/m, temperature rise (ΔT) and specific loss power (SLP) measured on magnetoferritin nanoparticles with core size of 4.8 nm at 5 mg/mL were 14.2 °C (at 6 min) and 68.6 W/g, respectively. The SLP increased with core-size, Fe concentration, AMF frequency, and amplitude. Given that: (1) the SLP was insensitive to viscosity of glycerol-water solutions and (2) both the calculated effective relaxation time and the fitted relaxation time were closer to Néel relaxation time, we propose that the heating generation mechanism of magnetoferritin nanoparticles is dominated by the Néel relaxation. This work provides new insights into the heating efficiency of magnetoferritin and potential future applications for tumor magnetic hyperthermia treatment and heat-triggered drug release.

摘要

超顺磁性物质磁铁蛋白因其具有活性肿瘤靶向性的外层蛋白壳、尺寸均匀且可调的纳米级内部矿物核、单分散性以及良好的生物相容性，是一种用于肿瘤磁热疗的潜在生物纳米材料。在此，我们评估了磁铁蛋白纳米颗粒在交变磁场（AMF）中的加热效率。研究了核尺寸、铁浓度、粘度以及场频率和振幅的影响。在805.5 kHz和19.5 kA/m条件下，对于浓度为5 mg/mL、核尺寸为4.8 nm的磁铁蛋白纳米颗粒，测得的温度升高（ΔT）和比损耗功率（SLP）分别为14.2℃（在6分钟时）和68.6 W/g。SLP随核尺寸、铁浓度、AMF频率和振幅的增加而增加。鉴于：（1）SLP对甘油 - 水溶液的粘度不敏感；（2）计算得到的有效弛豫时间和拟合弛豫时间都更接近奈尔弛豫时间，我们提出磁铁蛋白纳米颗粒的发热机制主要由奈尔弛豫主导。这项工作为磁铁蛋白的加热效率以及肿瘤磁热疗和热触发药物释放的潜在未来应用提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/c989713131c3/nanomaterials-09-01457-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/5dc26760c212/nanomaterials-09-01457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/193eb14bcd2e/nanomaterials-09-01457-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/5ac795056ad8/nanomaterials-09-01457-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/fb38b91ca665/nanomaterials-09-01457-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/5c813d1c287d/nanomaterials-09-01457-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/9cdcfb0569f6/nanomaterials-09-01457-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/59fb0be5bc33/nanomaterials-09-01457-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/f644c87bbd1b/nanomaterials-09-01457-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/3064bec39ddf/nanomaterials-09-01457-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/c989713131c3/nanomaterials-09-01457-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/5dc26760c212/nanomaterials-09-01457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/193eb14bcd2e/nanomaterials-09-01457-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/5ac795056ad8/nanomaterials-09-01457-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/fb38b91ca665/nanomaterials-09-01457-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/5c813d1c287d/nanomaterials-09-01457-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/9cdcfb0569f6/nanomaterials-09-01457-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/59fb0be5bc33/nanomaterials-09-01457-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/f644c87bbd1b/nanomaterials-09-01457-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/3064bec39ddf/nanomaterials-09-01457-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fba/6835341/c989713131c3/nanomaterials-09-01457-g010.jpg

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Int J Mol Sci. 2022-4-4

[3]
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[4]
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[5]
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本文引用的文献

[1]
Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles.

Pharmaceutics. 2019-6-11

[2]
Superparamagnetic iron oxide nanoparticulate system: synthesis, targeting, drug delivery and therapy in cancer.

Dalton Trans. 2019-7-2

[3]
Applications of magnetic materials separation in biological nanomedicine.

Electrophoresis. 2019-2-27

[4]
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications.

Adv Drug Deliv Rev. 2019-1-11

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Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles.

Nanoscale. 2019-2-7

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Recent advances in magnetic fluid hyperthermia for cancer therapy.

Colloids Surf B Biointerfaces. 2018-10-24

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A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages.

ACS Nano. 2014-4-8

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Adv Mater. 2014-2-14

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Int J Hyperthermia. 2013-8-22

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Learning from nature to improve the heat generation of iron-oxide nanoparticles for magnetic hyperthermia applications.

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