Darwish Mohamed S A, Kim Hohyeon, Lee Hwangjae, Ryu Chiseon, Young Lee Jae, Yoon Jungwon
School of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Petrochemical Department, Egyptian Petroleum Research Institute, 1 Ahmed El-Zomor Street, El Zohour Region, Nasr City, Cairo 11727, Egypt.
Nanomaterials (Basel). 2020 May 21;10(5):991. doi: 10.3390/nano10050991.
Magnetic ferrite nanoparticles (MFNs) with high heating efficiency are highly desirable for hyperthermia applications. As conventional MFNs usually show low heating efficiency with a lower specific loss power (), extensive efforts to enhance the of MFNs have been made by varying the particle compositions, sizes, and structures. In this study, we attempted to increase the values by creating core-shell structures of MFNs. Accordingly, first we synthesized three different types of core ferrite nanoparticle of magnetite (mag), cobalt ferrite (cf) and zinc cobalt ferrite (zcf). Secondly, we synthesized eight bi-magnetic core-shell structured MFNs; FeO@CoFeO (mag@cf, mag@cf), CoFeO@FeO (cf@mag, cf@mag), FeO@ZnCoFeO (mag@zcf, mag@zcf), and ZnCoFeO@FeO (zcf@mag, zcf@mag), using a modified controlled co-precipitation process. values of the prepared core-shell MFNs were investigated with respect to their compositions and core/shell dimensions while varying the applied magnetic field strength. Hyperthermia properties of the prepared core-shell MFNs were further compared to commercial magnetic nanoparticles under the safe limits of magnetic field parameters (<5 × 10 A/(m·s)). As a result, the highest value (379.2 W/g) was obtained for mag@zcf, with a magnetic field strength of 50 kA/m and frequency of 97 kHz. On the other hand, the lowest value (1.7 W/g) was obtained for cf@mag, with a magnetic field strength of 40 kA/m and frequency of 97 kHz. We also found that magnetic properties and thickness of the shell play critical roles in heating efficiency and hyperthermia performance. In conclusion, we successfully enhanced the of MFNs by engineering their compositions and dimensions.
具有高加热效率的磁性铁氧体纳米颗粒（MFNs）在热疗应用中极具吸引力。由于传统的MFNs通常具有较低的加热效率和较低的比损耗功率（ ），因此人们通过改变颗粒组成、尺寸和结构，为提高MFNs的 做出了广泛努力。在本研究中，我们试图通过创建MFNs的核壳结构来提高 值。因此，首先我们合成了三种不同类型的核铁氧体纳米颗粒，分别是磁铁矿（mag）、钴铁氧体（cf）和锌钴铁氧体（zcf）。其次，我们使用改进的可控共沉淀法合成了八种双磁性核壳结构的MFNs；FeO@CoFeO（mag@cf，mag@cf）、CoFeO@FeO（cf@mag，cf@mag）、FeO@ZnCoFeO（mag@zcf，mag@zcf）和ZnCoFeO@FeO（zcf@mag，zcf@mag）。在改变施加磁场强度的同时，研究了制备的核壳MFNs的 值与其组成和核/壳尺寸的关系。在磁场参数的安全极限（<5×10 A/（m·s））下，将制备的核壳MFNs的热疗性能与商业磁性纳米颗粒进行了进一步比较。结果，在磁场强度为50 kA/m、频率为97 kHz时，mag@zcf获得了最高的 值（379.2 W/g）。另一方面，在磁场强度为40 kA/m、频率为97 kHz时，cf@mag获得了最低的 值（1.7 W/g）。我们还发现，壳层的磁性和厚度在加热效率和热疗性能中起着关键作用。总之，我们通过设计MFNs的组成和尺寸成功提高了其 。
