成人T细胞白血病-淋巴瘤治疗的生物标志物与临床前模型
Biomarkers and Preclinical Models for Adult T-Cell Leukemia-Lymphoma Treatment.
作者信息
Ratner Lee
机构信息
Division of Oncology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
出版信息
Front Microbiol. 2019 Sep 18;10:2109. doi: 10.3389/fmicb.2019.02109. eCollection 2019.
Abstract
Adult T-cell leukemia/lymphoma (ATL) is an aggressive lymphoproliferative malignancy with a very poor prognosis. Despite several recent advances, new therapeutic approaches are critical, and this will require successful preclinical studies, including studies in ATL cell culture systems, and mouse models. Identification of accurate, reproducible biomarkers will be a crucial component of preclinical and clinical studies. This review summarizes the current state-of-the-art in each of these fields, and provides recommendations for future approaches. This problem is an important unmet need in HTLV research.
摘要
成人T细胞白血病/淋巴瘤（ATL）是一种侵袭性淋巴增殖性恶性肿瘤，预后极差。尽管最近有多项进展，但新的治疗方法至关重要，这将需要成功的临床前研究，包括在ATL细胞培养系统和小鼠模型中的研究。鉴定准确、可重复的生物标志物将是临床前和临床研究的关键组成部分。本综述总结了这些领域中每个领域的当前最新技术，并为未来的方法提供了建议。这个问题是HTLV研究中一个重要的未满足需求。
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