Division of Infectious Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan; Center for Tropical Medicine and Infectious Disease, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Center for Tropical Medicine and Infectious Disease, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
J Microbiol Immunol Infect. 2020 Dec;53(6):925-935. doi: 10.1016/j.jmii.2019.09.005. Epub 2019 Sep 30.
Galectins are β-Galactose binding lectins expressed in numerous cells and play multiple roles in various physiological and cellular functions. However, few information is available regarding the role of galectins in virus infections. Here, we conducted a systemic literature review to analyze the role of galectins in human virus infection.
This study uses a systematic method to identify and select eligible articles according to the PRISMA guidelines. References were selected from PubMed, Web of Science and Google Scholar database covering publication dated from August 1995 to December 2018.
Results indicate that galectins play multiple roles in regulation of virus infections. Galectin-1 (Gal-1), galectin-3 (Gal-3), galectin-8 (Gal-8), and galectin-9 (Gal-9) were found as the most predominant galectins reported to participate in virus infection. The regulatory function of galectins occurs by extracellularly binding to viral glycosylated envelope proteins, interacting with ligands or receptors on immune cells, or acting intracellularly with viral or cellular components in the cytoplasm. Several galectins express either positive or negative regulatory role, while some had dual regulatory capabilities on virus propagation based on the conditions and their localization. However, limited information about the endogenous function of galectins were found. Therefore, the endogenous effects of galectins in host-virus regulation remains valuable to investigate.
This study offers information regarding the various roles galectins shown in viral infection and suggest that galectins can potentially be used as viral therapeutic targets or antagonists.
半乳糖凝集素是一种表达于多种细胞的β-半乳糖结合凝集素，在多种生理和细胞功能中发挥多种作用。然而，关于半乳糖凝集素在病毒感染中的作用的信息很少。在这里，我们进行了系统的文献综述，以分析半乳糖凝集素在人类病毒感染中的作用。
本研究采用系统方法，根据 PRISMA 指南确定和选择合格的文章。参考文献选自 PubMed、Web of Science 和 Google Scholar 数据库，涵盖 1995 年 8 月至 2018 年 12 月的出版物。
结果表明，半乳糖凝集素在调节病毒感染中发挥多种作用。Galectin-1（Gal-1）、Galectin-3（Gal-3）、Galectin-8（Gal-8）和 Galectin-9（Gal-9）被发现是参与病毒感染的最主要的半乳糖凝集素。半乳糖凝集素的调节功能通过细胞外与病毒糖基化包膜蛋白结合、与免疫细胞上的配体或受体相互作用、或在细胞质中与病毒或细胞成分发生相互作用来实现。一些半乳糖凝集素表现出正或负的调节作用，而一些半乳糖凝集素根据条件和定位具有双重调节病毒增殖的能力。然而，关于半乳糖凝集素的内源性功能的信息有限。因此，研究半乳糖凝集素在宿主-病毒调节中的内源性作用仍然具有重要价值。
本研究提供了关于半乳糖凝集素在病毒感染中表现出的各种作用的信息，并表明半乳糖凝集素可能可作为病毒治疗靶点或拮抗剂。
