外泌体微小RNA在口腔扁平苔藓发病机制中的潜在作用
Possible roles of exosomal miRNAs in the pathogenesis of oral lichen planus.
作者信息
Li Congcong, He Hong, Wang Jiaqin, Xia Xinyu, Zhang Mengyun, Wu Qingzhu
机构信息
Affiliated Stomatology Hospital, School of Medicine, Zhejiang University 395 Yanan Road, Hangzhou 310006, Zhejiang Province, China.
Zhenjiang Stomatology Hospital Zhenjiang 212000, Jiangsu Province, China.
出版信息
Am J Transl Res. 2019 Sep 15;11(9):5313-5323. eCollection 2019.
Abstract
The etiology and pathogenesis of oral lichen planus have not achieved a consensus yet. This study aimed to explore the possible roles of exosomal miRNAs in the pathogenesis of oral lichen planus. Bioactive components from exosomes regulate intercellular communications that may be closely related to the occurrence and development of diseases, including oral lichen planus. Further, exosomes are expected to be a biomarker for the diagnosis and treatment of oral lichen planus. In this study, new advanced views about the biological characteristics, clinical significance, and involvement of exosomes in oral lichen planus were reviewed.
摘要
口腔扁平苔藓的病因和发病机制尚未达成共识。本研究旨在探讨外泌体微小RNA在口腔扁平苔藓发病机制中的可能作用。外泌体中的生物活性成分调节细胞间通讯，这可能与包括口腔扁平苔藓在内的疾病的发生和发展密切相关。此外，外泌体有望成为口腔扁平苔藓诊断和治疗的生物标志物。在本研究中，对外泌体在口腔扁平苔藓中的生物学特性、临床意义及参与情况的新的先进观点进行了综述。
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