Pediatric Endocrinology Research Group, (Girona Biomedical Research Institute) IDIBGI, Salt, Spain.
Department of Pediatrics, Dr. Trueta University Hospital, Girona, Spain.
J Clin Endocrinol Metab. 2020 Jan 1;105(1). doi: 10.1210/clinem/dgz101.
To study the association between insulin-like growth factor 1 (IGF-1) and blood pressure in children, in particular, the potential interaction with the serum calcium-phosphorus product (Ca*P).
A longitudinal study included 521 children (age 8.8 ± 0.1) from northeastern Spain, of whom 158 were followed-up after 5 years. IGF-1, insulin-like growth factor-binding protein 3 (IGFBP-3), and serum calcium and phosphorus were measured at baseline. Anthropometric (body-mass index [BMI] and waist) and cardiometabolic variables (systolic [SBP] and diastolic blood pressure), pulse pressure, insulin, homeostatic model assessment of insulin resistance [HOMA-IR], high-density lipoprotein [HDL]-cholesterol, and triglycerides) were assessed at baseline and at the end of follow-up. Statistical analysis included Pearson correlations followed by multivariable linear regression analyses.
Baseline IGF-1 and IGF-1/IGFBP-3 molar ratio positively correlated with baseline and follow-up BMI, waist, SBP, pulse pressure, insulin, HOMA-IR and triglycerides (r 0.138-0.603; all P < 0.05). The associations with SBP were stronger with increasing CaP (r 0.261-0.625 for IGF-1; and r 0.174-0.583 for IGF-1/IGFBP-3). After adjusting for confounding variables, baseline IGF-1 and IGF-1/IGFBP-3 remained independently associated with both baseline and follow-up SBP in children in the highest CaP tertile (β = 0.245-0.381; P < 0.01; model R2 = 0.246-0.566).
Our results suggest that IGF-1 in childhood is an independent predictor of SBP in apparently healthy children, especially in those with high Ca*P levels.
研究胰岛素样生长因子 1（IGF-1）与儿童血压之间的关系，特别是与血清钙磷乘积（Ca*P）的潜在相互作用。
一项纵向研究纳入了来自西班牙东北部的 521 名儿童（年龄 8.8±0.1 岁），其中 158 名儿童在 5 年后进行了随访。在基线时测量了 IGF-1、胰岛素样生长因子结合蛋白 3（IGFBP-3）以及血清钙和磷。在基线和随访结束时评估了人体测量学（体重指数[BMI]和腰围）和心脏代谢变量（收缩压[SBP]和舒张压）、脉压、胰岛素、稳态模型评估的胰岛素抵抗[HOMA-IR]、高密度脂蛋白[HDL]-胆固醇和甘油三酯）。统计分析包括 Pearson 相关性分析，随后进行多元线性回归分析。
基线 IGF-1 和 IGF-1/IGFBP-3 摩尔比值与基线和随访时的 BMI、腰围、SBP、脉压、胰岛素、HOMA-IR 和甘油三酯呈正相关（r 值为 0.138-0.603；均 P<0.05）。随着 CaP 的增加，与 SBP 的相关性更强（IGF-1 的 r 值为 0.261-0.625；IGF-1/IGFBP-3 的 r 值为 0.174-0.583）。在校正混杂因素后，在 CaP 最高三分位组的儿童中，基线 IGF-1 和 IGF-1/IGFBP-3 仍与基线和随访时的 SBP 独立相关（β=0.245-0.381；P<0.01；模型 R2=0.246-0.566）。
我们的结果表明，儿童时期的 IGF-1 是血压的独立预测因子，尤其是在血钙磷乘积较高的儿童中。
