Guo Xiaoyuan, Qiang Jiaqi, Zhou Zhibo, Sun Yuxin, Wang Yutong, Zhang Yuelun, Yang Hongbo, Zhu Huijuan, Zhang Mei, Ban Bo, Chen Shi, Pan Hui
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Endocrinol Invest. 2025 May 5. doi: 10.1007/s40618-025-02562-z.
The study aims to investigate associations between insulin sensitivity and insulin-like growth factor-1 (IGF-1) in adolescents engaged in long-term exercise training, and to assess the impact on growth.
We conducted a prospective cohort study and followed for 1 year from a general high school (non-exercise group, age 13.3 ± 0.5 years, n = 149) and an exercise training school (exercise group, age 13.5 ± 1.3 years, n = 100). Growth indices, insulin sensitivity assessed using the Quantitative Insulin Sensitivity Check Index (QUICKI), and IGF-1 levels were obtained.
Participants in the exercise group exhibited higher QUICKI and lower IGF-1 levels. In the exercise group, IGF-1 was independently associated with QUICKI cross-sectionally at baseline and follow-up. Longitudinal analysis revealed that QUICKI at baseline was independently associated with IGF-1 levels at follow-up in the exercise group (β = -532.926, P = 0.032). Such associations were not found in non-exercise group. Additionally, no impairments in growth indices were observed in the exercise group.
Our findings suggest that QUICKI is an independent predictor of IGF-1 levels in adolescents with a long-term exercise regimen.
本研究旨在调查长期进行运动训练的青少年中胰岛素敏感性与胰岛素样生长因子-1（IGF-1）之间的关联，并评估其对生长的影响。
我们进行了一项前瞻性队列研究，从一所普通高中（非运动组，年龄13.3±0.5岁，n = 149）和一所运动训练学校（运动组，年龄13.5±1.3岁，n = 100）随访1年。获取生长指标、使用定量胰岛素敏感性检查指数（QUICKI）评估的胰岛素敏感性以及IGF-1水平。
运动组参与者的QUICKI较高，IGF-1水平较低。在运动组中，IGF-1在基线和随访时与QUICKI呈横断面独立相关。纵向分析显示，运动组中基线时的QUICKI与随访时的IGF-1水平独立相关（β = -532.926，P = 0.032）。在非运动组中未发现此类关联。此外，运动组未观察到生长指标受损。
我们的研究结果表明，QUICKI是长期运动方案青少年中IGF-1水平的独立预测因子。
