Brugnoli Federica, Grassilli Silvia, Al-Qassab Yasamin, Capitani Silvano, Bertagnolo Valeria
Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
College of Medicine, University of Baghdad, Baghdad, Iraq.
J Oncol. 2019 Sep 16;2019:7512632. doi: 10.1155/2019/7512632. eCollection 2019.
Initially correlated with hematopoietic precursors, the surface expression of CD133 was also found in epithelial and nonepithelial cells from adult tissues in which it has been associated with a number of biological events. CD133 is expressed in solid tumors as well, including breast cancer, in which most of the studies have been focused on its use as a surface marker for the detection of cells with stem-like properties (i.e., cancer stem cells (CSCs)). Differently with other solid tumors, very limited and in part controversial are the information about the significance of CD133 in breast cancer, the most common malignancy among women in industrialized countries. In this review, we summarize the latest findings about the implication of CD133 in breast tumors, highlighting its role in tumor cells with a triple negative phenotype in which it directly regulates the expression of proteins involved in metastasis and drug resistance. We provide updates about the prognostic role of CD133, underlining its value as an indicator of increased malignancy of both noninvasive and invasive breast tumor cells. The molecular mechanisms at the basis of the regulation of CD133 levels in breast tumors have also been reviewed, highlighting experimental strategies capable to restrain its level that could be taken into account to reduce malignancy and/or to prevent the progression of breast tumors.
CD133的表面表达最初与造血前体细胞相关，后来在成体组织的上皮细胞和非上皮细胞中也被发现，且与许多生物学事件有关。CD133也在实体瘤中表达，包括乳腺癌，其中大多数研究都集中在将其用作检测具有干细胞样特性的细胞（即癌症干细胞（CSCs））的表面标志物。与其他实体瘤不同，关于CD133在乳腺癌（工业化国家女性中最常见的恶性肿瘤）中的意义的信息非常有限且部分存在争议。在这篇综述中，我们总结了关于CD133在乳腺肿瘤中的影响的最新发现，强调了它在具有三阴性表型的肿瘤细胞中的作用，在这种表型中它直接调节参与转移和耐药的蛋白质的表达。我们提供了关于CD133预后作用的最新信息，强调了它作为非侵袭性和侵袭性乳腺肿瘤细胞恶性程度增加指标的价值。还综述了乳腺肿瘤中CD133水平调节的分子机制，强调了能够抑制其水平的实验策略，这些策略可用于降低恶性程度和/或预防乳腺肿瘤的进展。
