Tian Xiao-Ting, Xu Ying-Jia, Yang Yi-Qing
Department of Cardiology, Cardiovascular Research Laboratory, and Center Laboratory, The Fifth People's Hospital of Shanghai, Fudan University, No. 801 Heqing Road, Shanghai, 200240, China.
J Cardiovasc Transl Res. 2020 Feb;13(1):85-96. doi: 10.1007/s12265-019-09918-w. Epub 2019 Oct 21.
There are significant differences in clinical presentation and treatment of atrial fibrillation (AF) between women and men. The primary goal of AF management is to restore sinus rhythm and to prevent various complications, including stroke and heart failure. In many areas of AF, such as prevalence, clinical manifestations, morbidity, risk factors, pathophysiology, treatment strategies, and complications, gender-specific variability is observed and needs to be further addressed by large-scale population researches or randomized clinical trials, which help to promote the customization of AF treatment programs, hence to maximize the success rate of AF therapy in both sexes. This review highlights our current understanding of these gender differences in AF and how these differences affect treatment decisions on AF.
心房颤动（AF）在女性和男性中的临床表现及治疗存在显著差异。房颤管理的主要目标是恢复窦性心律并预防包括中风和心力衰竭在内的各种并发症。在房颤的许多方面，如患病率、临床表现、发病率、危险因素、病理生理学、治疗策略及并发症等，均观察到了性别特异性差异，需要通过大规模人群研究或随机临床试验进一步探讨，这有助于推动房颤治疗方案的个性化，从而最大限度提高两性房颤治疗的成功率。本综述着重介绍了我们目前对房颤中这些性别差异的理解，以及这些差异如何影响房颤治疗决策。
