Department of Microbiology, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, Carpio y Plan de Ayala S/N, Col. Santo Tomás, Del. Miguel Hidalgo, 11340, Mexico City, Mexico.
Laboratory of Infectology, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Del. Tlalpan, 14389, Mexico City, Mexico.
Mol Biol Rep. 2020 Jan;47(1):771-784. doi: 10.1007/s11033-019-05139-1. Epub 2019 Oct 22.
Currently, the treatment of infections by Staphylococcus epidermidis (S. epidermidis) represents a challenge because some strains have multidrug-resistance to antimicrobial products (antibiotic and biocides) and can produce biofilms. These biofilms protect bacterial cells from both antimicrobials and the host immune response. Therefore, it is crucial to encourage research on the development of new treatments. One method is immunotherapy, targeting components of S. epidermidis, such as S. epidermidis surface (Ses) proteins. Ses is expressed constitutively in most strains, and they participate in biofilm formation. This review is an update on Ses, regarding their structure, biological function, their relationship with S. epidermidis biofilm formation, and its possible role as therapeutic targets to develop immunotherapeutic treatments to prevent infections by S. epidermidis.
目前，表皮葡萄球菌（S. epidermidis）感染的治疗是一个挑战，因为一些菌株对抗菌产品（抗生素和杀生物剂）具有多药耐药性，并且能够产生生物膜。这些生物膜可以保护细菌细胞免受抗生素和宿主免疫反应的影响。因此，鼓励研究开发新的治疗方法非常重要。一种方法是免疫疗法，针对表皮葡萄球菌的成分，例如表皮葡萄球菌表面（Ses）蛋白。Ses 在大多数菌株中组成性表达，并且它们参与生物膜的形成。这篇综述更新了 Ses 的结构、生物学功能、与表皮葡萄球菌生物膜形成的关系以及作为治疗靶点的可能作用，以开发免疫治疗方法来预防表皮葡萄球菌感染。
