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Histone lactylation links metabolism and gene regulation.

作者信息

Izzo Luke T, Wellen Kathryn E

出版信息

Nature. 2019 Oct;574(7779):492-493. doi: 10.1038/d41586-019-03122-1.

DOI:10.1038/d41586-019-03122-1

PMID:31645737

Abstract

摘要

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Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle.

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相似文献

Histone lactylation links metabolism and gene regulation.

Nature. 2019 Oct;574(7779):492-493. doi: 10.1038/d41586-019-03122-1.

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Trends Biochem Sci. 2020 Mar;45(3):179-182. doi: 10.1016/j.tibs.2019.12.004. Epub 2019 Dec 31.

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Immunity. 2019 Dec 17;51(6):980-981. doi: 10.1016/j.immuni.2019.11.008.

Lactate, histone lactylation and cancer hallmarks.

Expert Rev Mol Med. 2023 Jan 9;25:e7. doi: 10.1017/erm.2022.42.

Histone variants: key players of chromatin.

Cell Tissue Res. 2014 Jun;356(3):457-66. doi: 10.1007/s00441-014-1862-4. Epub 2014 Apr 30.

Lactylation: a Passing Fad or the Future of Posttranslational Modification.

Inflammation. 2022 Aug;45(4):1419-1429. doi: 10.1007/s10753-022-01637-w. Epub 2022 Feb 27.

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Mol Membr Biol. 2012 Nov;29(7):257-66. doi: 10.3109/09687688.2012.729094. Epub 2012 Oct 24.

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Mol Biochem Parasitol. 2012 Jun;183(2):105-14. doi: 10.1016/j.molbiopara.2012.03.001. Epub 2012 Mar 10.

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Biochim Biophys Acta. 2016 Mar;1859(3):520-5. doi: 10.1016/j.bbagrm.2015.10.016. Epub 2015 Oct 27.

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J Biochem. 2001 Apr;129(4):491-9. doi: 10.1093/oxfordjournals.jbchem.a002882.

引用本文的文献

Effects of lactylation on the hallmarks of cancer (Review).

Oncol Lett. 2025 Aug 20;30(5):492. doi: 10.3892/ol.2025.15238. eCollection 2025 Nov.

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Front Cell Dev Biol. 2025 Aug 13;13:1533175. doi: 10.3389/fcell.2025.1533175. eCollection 2025.

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J Transl Med. 2025 Aug 19;23(1):941. doi: 10.1186/s12967-025-06959-5.

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Curr Med Sci. 2025 Jun;45(3):415-429. doi: 10.1007/s11596-025-00049-9. Epub 2025 May 21.

本文引用的文献

Metabolic regulation of cell growth and proliferation.

Nat Rev Mol Cell Biol. 2019 Jul;20(7):436-450. doi: 10.1038/s41580-019-0123-5.

Lactate: A Metabolic Driver in the Tumour Landscape.

Trends Biochem Sci. 2019 Feb;44(2):153-166. doi: 10.1016/j.tibs.2018.10.011. Epub 2018 Nov 22.

Metabolic Signaling to the Nucleus in Cancer.

Mol Cell. 2018 Aug 2;71(3):398-408. doi: 10.1016/j.molcel.2018.07.015.

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle.

Cell Metab. 2017 Dec 5;26(6):803-804. doi: 10.1016/j.cmet.2017.11.005.

Metabolic regulation of gene expression through histone acylations.

Nat Rev Mol Cell Biol. 2017 Feb;18(2):90-101. doi: 10.1038/nrm.2016.140. Epub 2016 Dec 7.

Intermediates of Metabolism: From Bystanders to Signalling Molecules.

Trends Biochem Sci. 2016 May;41(5):460-471. doi: 10.1016/j.tibs.2016.02.003. Epub 2016 Feb 28.

Metabolic reprograming in macrophage polarization.

Front Immunol. 2014 Sep 2;5:420. doi: 10.3389/fimmu.2014.00420. eCollection 2014.