通过原位过酸进行化学酶氧化的定制。
Tailoring chemoenzymatic oxidation via in situ peracids.
机构信息
Department of Chemistry and Biochemistry, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
出版信息
Org Biomol Chem. 2019 Nov 6;17(43):9418-9424. doi: 10.1039/c9ob01814j.
Abstract
Epoxidation chemistry often suffers from the challenging handling of peracids and thus requires in situ preparation. Here, we describe a two-phase enzymatic system that allows the effective generation of peracids and directly translate their activity to the epoxidation of olefins. We demonstrate the approach by application to lipid and olefin epoxidation as well as sulfide oxidation. These methods offer useful applications to synthetic modifications and scalable green processes.
摘要
环氧化化学常常受到过酸难以处理的困扰，因此需要原位制备。在这里，我们描述了一种两相酶系统，该系统允许有效地生成过酸，并直接将其活性转化为烯烃的环氧化反应。我们通过应用于脂质和烯烃的环氧化以及硫化物氧化来证明该方法。这些方法为合成修饰和可扩展的绿色工艺提供了有用的应用。
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