Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629HZ, Delft, The Netherlands.
School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, P. R. China.
Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9238-9261. doi: 10.1002/anie.201800343. Epub 2018 Jul 3.
Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H bonds. For many of these reactions, no "classical" chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes based on a more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. In this Review, we critically summarise the most important recent developments in the field of biocatalytic oxidation chemistry and identify the most pressing bottlenecks as well as promising solutions.
利用酶的氧化化学在有机合成中已经接近成熟和实用。氧化还原酶（催化氧化还原反应的酶）使化学家能够进行高度选择性和高效的转化，从简单的醇氧化到非活化 C-H 键的立体选择性卤化。对于许多这些反应，没有已知的“经典”化学对应物。因此，氧化还原酶开辟了更短的合成路线，更直接地通向目标产物。与经典对应物相比，通常非常温和的反应条件也可能降低生物催化反应对环境的影响。在这篇综述中，我们批判性地总结了生物催化氧化化学领域的最新重要进展，并确定了最紧迫的瓶颈以及有前途的解决方案。
