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小肠克罗恩病患者体内视频胶囊滞留1年后自然排出:一例报告

Natural elimination of a video capsule after retention for 1 year in a patient with small bowel Crohn disease: A case report.

作者信息

Lee So Yeon, Lee Ju Yup, Lee Yoo Jin, Park Kyung Sik

机构信息

Department of Internal Medicine, Keimyung University School of Medicine, Dalseo-gu, Daegu, Republic of Korea.

出版信息

Medicine (Baltimore). 2019 Oct;98(43):e17580. doi: 10.1097/MD.0000000000017580.

Abstract

INTRODUCTION

Video capsule endoscopy (VCE) is a useful tool to differentiate small intestinal bleeding, inflammatory bowel disease, and other small bowel disease. The most common adverse effect of VCE is capsule retention; the incidence varies greatly depending on the underlying disease, which is known to increase from 1.5% in healthy individuals to 21% in patients with small bowel Crohn disease. We report this case on a patient who had asymptomatic capsule retention for 12 months and experienced natural elimination with medication.

PATIENT CONCERNS

A 21-year-old woman presented to the hospital with chronic abdominal pain and persistent diarrhea for 2 years.

DIAGNOSES

The patient was diagnosed with small bowel Crohn disease using VCE, and radiography revealed capsule retention.

INTERVENTION

Symptoms of obstruction were not distinctive, it was decided to increase the dosages of azathioprine and infliximab to 50 and 500 mg (10 mg/kg), at 5 months after VCE. And at month 11 of capsule retention, she was admitted and started on a regimen of hydrocortisol 300 mg for 4 days and hydrocortisol injection 200 mg for 10 days.

OUTCOMES

At month 12, abdominal radiography in the clinic confirmed that the capsule had been naturally retrieved.

LESSONS

Capsule retention could be initially treated conservatively with medication and if the treatment fails, it is recommended to remove the capsule surgically. But in the case of the clinical condition of the patient is favorable without symptoms of bowel obstruction, the medication should be continued and the patient followed up.

摘要

引言

视频胶囊内镜检查(VCE)是鉴别小肠出血、炎症性肠病及其他小肠疾病的有用工具。VCE最常见的不良反应是胶囊滞留;其发生率因基础疾病不同而有很大差异,已知在健康个体中为1.5%,在小肠克罗恩病患者中增至21%。我们报告此例患者,其无症状胶囊滞留达12个月,经药物治疗后自然排出。

患者情况

一名21岁女性因慢性腹痛和持续腹泻2年入院。

诊断

通过VCE诊断该患者为小肠克罗恩病,影像学检查显示胶囊滞留。

干预措施

梗阻症状不明显,在VCE检查后5个月,决定将硫唑嘌呤和英夫利昔单抗剂量分别增至50和500毫克(10毫克/千克)。在胶囊滞留第11个月时,患者入院,开始接受为期4天的300毫克氢化可的松及为期10天的200毫克氢化可的松注射治疗。

结果

在第12个月时,门诊腹部X线检查证实胶囊已自然排出。

经验教训

胶囊滞留最初可采用药物保守治疗,若治疗失败,建议手术取出胶囊。但如果患者临床状况良好且无肠梗阻症状,则应继续用药并对患者进行随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fd/6824652/064ef70f7612/medi-98-e17580-g001.jpg

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