Tang Yinshan, Shao Shujun, Zhou You, Xiong Bing, Cao Jin, Li Zhigang, Wu Jihong, Wang Chao
Department of Rehabilitation in Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou.
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Medicine (Baltimore). 2019 Oct;98(43):e17648. doi: 10.1097/MD.0000000000017648.
Vascular dementia (VaD) is the second prevalent dementia worldwide attributable to cognitive impairments. Acupuncture has been applied in clinic as a therapeutic modality to treat VaD. This systematic review and meta-analysis aims to evaluate current evidence to explore the effectiveness and safety of acupuncture treatment to cognitive impairment of VaD.
Randomized controlled trials will be searched restricted to their inception from January 1, 2000 to September 15, 2019. The following literature databases will be searched, including 4 English databases: PubMed, Excerpta Medica Database, the Cochrane Library, Medline, and 4 Chinese databases, namely the China National Knowledge Infrastructure Database, the Wanfang Database, the Chinese Scientific Journal Database, and the Chinese BioMedical Literature Database. After the selection and extraction of eligible studies, a meta-analysis will be undertaken to assess the efficacy and safety of acupuncture on VaD. The Review Manager Software V.5.3.5 will be employed for meta-analysis to assess the risk of bias, data synthesis, and subgroup analysis.
The systematic review and meta-analysis will be carried out to evaluate the efficacy and safety of acupuncture in the treatment of VaD, further provide an evidence-based synthesis for clinical and research applications.
The summary of our systematic review will determine whether acupuncture intervention to VaD is safe and well-tolerated in global status.
血管性痴呆（VaD）是全球第二常见的由认知障碍引起的痴呆症。针灸已在临床上作为治疗VaD的一种治疗方式应用。本系统评价和荟萃分析旨在评估现有证据，以探讨针刺治疗VaD认知障碍的有效性和安全性。
将检索2000年1月1日至2019年9月15日期间发表的随机对照试验。将检索以下文献数据库，包括4个英文数据库：PubMed、医学文摘数据库、Cochrane图书馆、Medline，以及4个中文数据库，即中国知网数据库、万方数据库、中国科学期刊数据库和中国生物医学文献数据库。在筛选和提取符合条件的研究后，将进行荟萃分析，以评估针刺治疗VaD的疗效和安全性。将使用Review Manager软件V.5.3.5进行荟萃分析，以评估偏倚风险、数据合成和亚组分析。
将进行系统评价和荟萃分析，以评估针刺治疗VaD的疗效和安全性，进一步为临床和研究应用提供循证综合。
我们系统评价的总结将确定在全球范围内针刺干预VaD是否安全且耐受性良好。
