Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Norwegian Institute of Public Health, Oslo, Norway.
Sci Rep. 2019 Oct 25;9(1):15328. doi: 10.1038/s41598-019-51527-9.
Seasonal variations have recently been described in biomarkers, cell types, and gene expression associated with the immune system, but so far no studies have been conducted among women in the peripartum period. It is of note that pregnancy complications and outcomes, as well as autoimmune diseases, have also been reported to exhibit seasonal fluctuations. We report here a clear-cut seasonal pattern of 23 inflammatory markers, analysed using proximity-extension assay technology, in pregnant women. The inflammatory markers generally peaked in the spring and had a trough in the autumn. During the postpartum period we found seasonality in one inflammatory marker, namely monocyte chemotactic protein 4 (MCP-4). Our findings suggest that seasonal variations in peripheral inflammatory markers are only observed during pregnancy. The results of this study could be valuable to professionals working within the field of immunology-related areas, and provide insight for the understanding of obstetric complications.
目前已经有研究描述了与免疫系统相关的生物标志物、细胞类型和基因表达的季节性变化，但迄今为止，尚未有针对围产期女性的相关研究。值得注意的是，妊娠并发症和结局以及自身免疫性疾病也被报道存在季节性波动。我们在此报告了一项使用邻近延伸分析技术对 23 种炎症标志物进行的明确的季节性研究，这些标志物在孕妇中呈现出春季高峰和秋季低谷的模式。在产后期间，我们发现有一种炎症标志物即单核细胞趋化蛋白 4（MCP-4）具有季节性。我们的研究结果表明，外周炎症标志物的季节性变化仅在怀孕期间观察到。本研究的结果可能对从事免疫学相关领域的专业人员具有重要价值，并为理解产科并发症提供了新的视角。
