Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
Essays Biochem. 2019 Oct 31;63(5):619-629. doi: 10.1042/EBC20190019.
In this review, we present recent findings on the dynamic nature of the tumour microenvironment (TME) and how intravital microscopy studies have defined TME components in a spatiotemporal manner. Intravital microscopy has shed light into the nature of the TME, revealing structural details of both tumour cells and other TME co-habitants in vivo, how these cells communicate with each other, and how they are organized in three-dimensional space to orchestrate tumour growth, invasion, dissemination and metastasis. We will review different imaging tools, imaging reporters and fate-mapping strategies that have begun to uncover the complexity of the TME in vivo.
在这篇综述中，我们介绍了肿瘤微环境（TME）动态性质的最新发现，以及活体显微镜研究如何以时空方式定义 TME 成分。活体显微镜揭示了 TME 的本质，揭示了肿瘤细胞和其他 TME 共栖物的结构细节，这些细胞如何相互交流，以及它们如何在三维空间中组织以协调肿瘤的生长、侵袭、扩散和转移。我们将回顾不同的成像工具、成像报告基因和命运映射策略，这些策略已经开始揭示体内 TME 的复杂性。
