Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, 951 BRB, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Br J Cancer. 2013 Mar 5;108(4):755-61. doi: 10.1038/bjc.2012.592. Epub 2013 Jan 15.
Matricellular proteins have been classified as a family of non-structural matrix proteins capable of modulating a variety of biological processes within the extracellular matrix (ECM). These proteins are expressed dynamically and their cellular functions are highly dependent upon cues from the local environment. Recent studies have shown an increasing appreciation of the key roles these ECM proteins play within the tumour microenvironment. Induced by either tumour cells or tumour stromal components, matricellular proteins initiate downstream signalling events that lead to proliferation, invasion, matrix remodelling and dissemination to pre-metastatic niches in other organs. In this review, we summarise and discuss the current knowledge of the diverse roles these proteins play within the microenvironment that influences tumour progression and potential for future therapies targeting the tumour microenvironment.
细胞外基质蛋白被归类为一组非结构基质蛋白，能够调节细胞外基质 (ECM) 中的多种生物学过程。这些蛋白质的表达具有动态性，其细胞功能高度依赖于局部环境的信号。最近的研究表明，人们越来越认识到这些 ECM 蛋白在肿瘤微环境中所起的关键作用。细胞外基质蛋白由肿瘤细胞或肿瘤基质成分诱导产生，启动下游信号事件，导致增殖、侵袭、基质重塑和向其他器官的转移前龛位扩散。在这篇综述中，我们总结和讨论了这些蛋白在影响肿瘤进展和针对肿瘤微环境的潜在未来治疗方法的微环境中发挥的多种作用的现有知识。
