Swash M, Scholtz C L, Vowles G, Ingram D A
Institute of Pathology, London Hospital Medical College, UK.
J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):785-9. doi: 10.1136/jnnp.51.6.785.
The spinal cords of 10 cases of motor neuron disease were compared with those of six age-matched controls using myelin and silver impregnation methods, and the Marchi reaction for myelin degradation products. These studies revealed striking asymmetry in involvement of the lateral and anterior corticospinal tracts, without concordance in the pattern of involvement of these crossed and uncrossed corticospinal pathways. In addition there was prominent involvement of the posterior and anterior spinocerebellar tracts, but less marked abnormality was seen in the reticulospinal pathways. These findings highlight the asymmetrical involvement of the upper and lower motor neuron components of the motor system that is a characteristic feature of the disease, and demonstrate that involvement of the spinocerebellar system is a frequent finding.
采用髓鞘染色和银浸染法以及对髓鞘降解产物的马基反应，对10例运动神经元病患者的脊髓与6例年龄匹配的对照者的脊髓进行了比较。这些研究揭示，外侧和皮质脊髓前束的受累存在明显不对称，这些交叉和未交叉的皮质脊髓通路的受累模式并不一致。此外，脊髓后和脊髓小脑前束有明显受累，但网状脊髓通路的异常不太明显。这些发现突出了运动系统上下运动神经元成分受累的不对称性，这是该疾病的一个特征，并且表明脊髓小脑系统受累是常见表现。
