The University of Queensland, Centre for Clinical Research, Herston, Brisbane, Australia; The Prince Charles Hospital, Brisbane, Australia.
The University of Queensland, Centre for Clinical Research, Herston, Brisbane, Australia; Pathology Queensland, Central Laboratory, Royal Brisbane and Women's Hospital, Herston, Australia.
Clin Microbiol Infect. 2020 Feb;26(2):257.e1-257.e4. doi: 10.1016/j.cmi.2019.10.011. Epub 2019 Oct 23.
To evaluate the sequential organ failure assessment (SOFA) and modified SOFA (mSOFA) scoring and a novel performance score based on the Karnofsky score for measuring outcome following a bloodstream infection (BSI).
This prospective observational cohort study assessed patients with BSI for mortality and functional outcomes with a novel performance score: the functional bloodstream infection score (FBIS). We also tested the SOFA and, given the difficulties with measuring SOFA on ward-based patients, the mSOFA over the first 7 days following a BSI for their association with outcomes.
One hundred participants were prospectively recruited. Mortality at 52 weeks following BSI was 21% (21/100). Only 57% of survivors (39/69) were at their baseline functional status at 52 weeks. Stable or improved SOFA/mSOFA over the first 7 days was associated with survival and return to premorbid performance score (risk ratio 3.2, 95%CI 1.3-9.4, p < 0.01).
The acute change in SOFA/mSOFA was associated with 52-week survival and return to premorbid functional performance. The FBIS measurement represents a simple and easy-to-apply measure of functional performance for patients with BSI and was associated with a high response rate (89%) from participants.
评估序贯器官衰竭评估（SOFA）和改良 SOFA（mSOFA）评分以及基于卡诺夫斯基评分的新型评分，以衡量血流感染（BSI）后的结局。
本前瞻性观察性队列研究评估了 BSI 患者的死亡率和功能结局，并采用新型功能血流感染评分（FBIS）进行评估。我们还测试了 SOFA，鉴于在基于病房的患者中测量 SOFA 存在困难，还测试了 mSOFA 在 BSI 后第 7 天内与结局的相关性。
前瞻性招募了 100 名参与者。BSI 后 52 周的死亡率为 21%（21/100）。只有 57%的幸存者（39/69）在 52 周时恢复到基线功能状态。第 1 天到第 7 天内 SOFA/mSOFA 稳定或改善与生存和恢复到发病前的功能评分相关（风险比 3.2，95%CI 1.3-9.4，p<0.01）。
SOFA/mSOFA 的急性变化与 52 周生存率和恢复到发病前的功能表现相关。FBIS 测量代表了一种简单易用的 BSI 患者功能表现的衡量方法，参与者的响应率高达 89%。
