Mirambo Mariam M, Mshana Stephen E, Groß Uwe
Department of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Institute of Medical Microbiology, Gottingen University Medical Centre, Germany.
Afr Health Sci. 2019 Jun;19(2):1858-1865. doi: 10.4314/ahs.v19i2.8.
A significant proportion of newborns in the developing countries are born with congenital anomalies.
This study investigated congenital infections due to Rubella virus, among presumed normal neonates from full term pregnant women in Mwanza, Tanzania.
Sera from mothers were tested for and infection while newborns from mothers with acute infections were tested for and , and all newborns were tested for Rubella IgM antibodies.
A total of 13/300 (4.3 %) mothers had antibodies with 3 of them having acute infection. Two (0.7 %) of the newborns from mothers with acute infection were confirmed to have congenital syphilis. Regarding toxoplasmosis, 92/300 (30.7 %) mothers were IgG seropositive and 7 had borderline positivity, with only 1/99 (1%) being IgM seropositive who delivered IgM seronegative neonate. Only 1/300 (0.3 %) newborn had rubella IgM antibodies indicating congenital rubella infection.
Based on these results, it is estimated that in Mwanza city in every 100,000 live births about 300 and 600 newborns have congenital rubella and syphilis infections, respectively. Rubella virus and are likely to be among common causes of congenital infections in developing countries.
发展中国家有相当比例的新生儿患有先天性畸形。
本研究调查了坦桑尼亚姆万扎足月孕妇中假定正常的新生儿感染风疹病毒导致的先天性感染情况。
检测母亲血清中的[此处原文缺失部分内容]和[此处原文缺失部分内容]感染情况，对急性感染母亲的新生儿检测[此处原文缺失部分内容]和[此处原文缺失部分内容]，并对所有新生儿检测风疹IgM抗体。
300名母亲中共有13名（4.3%）有[此处原文缺失部分内容]抗体，其中3名有急性感染。急性感染母亲的2名新生儿（0.7%）被确诊患有先天性梅毒。关于弓形虫病，300名母亲中有92名（30.7%）IgG血清学阳性，7名临界阳性，只有1名（1/99，1%）IgM血清学阳性，其分娩的新生儿IgM血清学阴性。仅1名新生儿（1/300，0.3%）有风疹IgM抗体，表明患有先天性风疹感染。
根据这些结果，估计在姆万扎市每10万例活产中分别约有300例和600例新生儿患有先天性风疹和梅毒感染。风疹病毒和[此处原文缺失部分内容]可能是发展中国家先天性感染的常见原因。
