（DC）叶水提取物的体外抗菌和细胞遗传毒理学特性。
In vitro antibacterial and cytogenotoxicological properties of the aqueous extract of (DC) leaf.
作者信息
Erhabor Joseph Omorogiuwa, Erhabor Rosemary Chinelo, Ldu MacDonald
机构信息
Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Sciences, University of Pretoria, South Africa.
出版信息
Afr Health Sci. 2019 Jun;19(2):2056-2067. doi: 10.4314/ahs.v19i2.29.
BACKGROUND
Microbial infection of the genital tract or semen is one of the leading causes of male infertility. Consequently, there is a need to seek alternative products from natural sources.
OBJECTIVES
The antibacterial, phytochemical and cytogenotoxicological assessments of the aqueous extract of leaf were evaluated.
METHODS
The antibacterial potential of the extract was done via agar-well diffusion and microdilution techniques. The phytochemical analysis was done via standard protocols.The cytogenotoxicity of the extract were analyzed using the assay.
RESULTS
All test organisms were found to be sensitive to the extract except where no measurable zone of inhibition could be ascertained at all concentrations assessed.The highest mean inhibition diameter of 21.33±1.20mm against was recorded and a concentration-dependent susceptibility noticed. The phytochemical results revealed the presence of saponins, flavonoid, glycoside, steroids, terpenoid and alkaloids. The root showed reduced mitotic indices following aconcentration-dependent increase in the extract.It can be said that the aqueous extract of had inhibitory activities against the tested pathogenic organisms with relative anti-tumour potential.
CONCLUSION
This study indicated, could be a potential source for antibacterial compounds for the possible treatment of male reproductive related infections.
背景
生殖道或精液的微生物感染是男性不育的主要原因之一。因此，有必要从天然来源寻找替代产品。
目的
对叶水提取物进行抗菌、植物化学和细胞遗传毒性评估。
方法
通过琼脂孔扩散法和微量稀释技术评估提取物的抗菌潜力。通过标准方案进行植物化学分析。使用该试验分析提取物的细胞遗传毒性。
结果
除了在所有评估浓度下均未确定可测量的抑菌圈外，所有受试生物均对提取物敏感。对[具体受试生物]的最高平均抑菌直径记录为21.33±1.20毫米，并观察到浓度依赖性敏感性。植物化学结果显示存在皂苷、黄酮类、糖苷、类固醇、萜类和生物碱。[具体受试生物]的根在提取物浓度依赖性增加后有丝分裂指数降低。可以说，[植物名称]的水提取物对受试致病生物具有抑制活性，并具有相对的抗肿瘤潜力。
结论
本研究表明，[植物名称]可能是抗菌化合物的潜在来源，可用于治疗男性生殖相关感染。
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