通过促进对参加临床试验邀请的知情回应来减少研究浪费。
Reducing research waste by promoting informed responses to invitations to participate in clinical trials.
机构信息
Health Services Research Unit, University of Aberdeen, Aberdeen, AB25 2ZB,, UK.
Centre for Evidence-Based Medicine, University of Oxford, Oxford, UK.
出版信息
Trials. 2019 Oct 28;20(1):613. doi: 10.1186/s13063-019-3704-x.
Abstract
Poor recruitment to, and retention in, clinical trials is a source of research waste that could be reduced by more informed choices about participation. Barriers to effective recruitment and retention can be wide-ranging but relevance of the questions being addressed by trials and the outcomes that they are assessing are key for potential participants. Decisions about trial participation should be informed by general and trial-specific information and by considering broader assessments of 'informedness' and how they impact on both recruitment and retention. We suggest that more informed decisions about trial participation should encourage personally appropriate decisions, increase recruitment and retention, and reduce research waste and increase its value.
摘要
临床试验中招募参与者和保留参与者的情况不佳是造成研究浪费的一个原因，而这种浪费可以通过更加明智地选择参与来减少。有效招募和保留参与者的障碍可能多种多样，但试验所解决问题的相关性以及它们评估的结果是潜在参与者的关键。关于试验参与的决策应该基于一般信息和试验特定信息，并考虑更广泛的“知情”评估及其对招募和保留的影响。我们建议，关于试验参与的更明智决策应该鼓励做出个人合适的决策，增加招募和保留，并减少研究浪费，提高其价值。
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