电化学氧化氨基酸实现脱羧 C-N 键形成。
Decarboxylative C-N Bond Formation by Electrochemical Oxidation of Amino Acids.
机构信息
Institute of Advanced Synthesis (IAS), School of Chemistry and Molecular Engineering , Nanjing Tech University , Nanjing 211816 , China.
Institute of Chemical Research of Catalonia (ICIQ) , Barcelona Institute of Science and Technology, Av. Països Catalans 16 , 43007 Tarragona , Spain.
出版信息
Org Lett. 2019 Nov 15;21(22):9262-9267. doi: 10.1021/acs.orglett.9b03696. Epub 2019 Oct 29.
Decarboxylative C-N coupling reactions have been developed through electrochemical oxidation of amino acids. The reaction proceeds via anodic oxidative decarboxylation of carboxylic acids to form stabilized carbocations, which are trapped by azoles or amides to construct C-N bonds. This method avoids the preactivation of carboxylic acids and the use of expensive transition-metals and external chemical oxidants.
通过氨基酸的电化学氧化，发展了脱羧 C-N 偶联反应。该反应通过羧酸的阳极氧化脱羧进行，形成稳定的碳正离子，然后被唑类或酰胺捕获，构建 C-N 键。这种方法避免了羧酸的预活化以及昂贵的过渡金属和外部化学氧化剂的使用。
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