Nosenko M A, Ambaryan S G, Drutskaya M S
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Immunology Department, Biological Faculty, Moscow State University, Moscow, 119234 Russia.
Mol Biol (Mosk). 2019 Sep-Oct;53(5):741-754. doi: 10.1134/S0026898419050136.
Skin wound healing is subject to an intricate regulation, involves many cell populations and molecular mediators, and is one of the key mechanisms that ensures the barrier functions of the skin and the maintenance of body homeostasis. The efficiency of this process is largely determined by the balance of proinflammatory and proregenerative signals, which are mediated by cytokines. The review summarizes the latest data on the role of proinflammatory cytokines, mainly tumor necrosis factor (TNF), interleukin 6 (IL-6), interleukin 1 (IL-1), and interferons (IFNs), in skin wound healing, including those obtained with the use of genome editing techniques and methods of reverse genetics to establish relevant animal models. The roles that proinflammatory cytokines play at various stages of skin regeneration are discussed for both normal state and systemic pathologies, such as diabetes. Promising approaches to treating poorly healing wounds are summarized.
皮肤伤口愈合受到复杂的调控，涉及许多细胞群体和分子介质，是确保皮肤屏障功能和维持身体内稳态的关键机制之一。这一过程的效率很大程度上取决于由细胞因子介导的促炎信号和促再生信号之间的平衡。本综述总结了促炎细胞因子，主要是肿瘤坏死因子（TNF）、白细胞介素6（IL-6）、白细胞介素1（IL-1）和干扰素（IFN）在皮肤伤口愈合中作用的最新数据，包括利用基因组编辑技术和反向遗传学方法建立相关动物模型所获得的数据。讨论了促炎细胞因子在正常状态和系统性疾病（如糖尿病）下皮肤再生各个阶段所起的作用。总结了治疗愈合不良伤口的有前景的方法。
