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在应用负载L提取物的双凝胶后大鼠模型中的组织再生与重塑

Tissue Regeneration and Remodeling in Rat Models after Application of L. Extract-Loaded Bigels.

作者信息

Sotirova Yoana, Kiselova-Kaneva Yoana, Vankova Deyana, Tasinov Oskan, Ivanova Diana, Popov Hristo, Hristova Minka, Nikolova Krastena, Andonova Velichka

机构信息

Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna, 9000 Varna, Bulgaria.

Department of Biochemistry, Molecular Medicine and Nutrigenomics, Faculty of Pharmacy, Medical University of Varna, 9000 Varna, Bulgaria.

出版信息

Gels. 2024 May 17;10(5):341. doi: 10.3390/gels10050341.

DOI:10.3390/gels10050341
PMID:38786258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11121646/
Abstract

The wound-healing effect of St. John's Wort (SJW) is mainly attributed to hyperforin (HP), but its low stability restricts its topical administration. This study investigates how "free" HP-rich SJW extract (incorporated into a bigel; B/SJW) and extract "protected" by nanostructured lipid carriers (also included in a biphasic semisolid; B/NLC-SJW) affect tissue regeneration in a rat skin excision wound model. Wound diameter, histological changes, and tissue gene expression levels of fibronectin (Fn), matrix metalloproteinase 8 (MMP8), and tumor necrosis factor-alpha (TNF-α) were employed to quantify the healing progress. A significant wound size reduction was achieved after applying both extract-containing semisolids, but after a 21-day application period, the smallest wound size was observed in the B/NLC-SJW-treated animals. However, the inflammatory response was affected more favorably by the bigel containing the "free" SJW extract, as evidenced by histological studies. Moreover, after the application of B/SJW, the expression of Fn, MMP8, and TNF-α was significantly higher than in the positive control. In conclusion, both bigel formulations exhibited beneficial effects on wound healing in rat skin, but B/SJW affected skin restoration processes in a comprehensive and more efficient way.

摘要

圣约翰草（SJW）的伤口愈合作用主要归因于金丝桃素（HP），但其稳定性低限制了其局部应用。本研究调查了“游离”富含HP的SJW提取物（掺入双凝胶中；B/SJW）和由纳米结构脂质载体“保护”的提取物（也包含在双相半固体中；B/NLC-SJW）在大鼠皮肤切除伤口模型中如何影响组织再生。采用伤口直径、组织学变化以及纤连蛋白（Fn）、基质金属蛋白酶8（MMP8）和肿瘤坏死因子-α（TNF-α）的组织基因表达水平来量化愈合进程。应用两种含提取物的半固体后伤口大小均显著减小，但在21天的应用期后，在接受B/NLC-SJW治疗的动物中观察到最小的伤口大小。然而，组织学研究表明，含“游离”SJW提取物的双凝胶对炎症反应的影响更有利。此外，应用B/SJW后，Fn、MMP8和TNF-α的表达显著高于阳性对照。总之，两种双凝胶制剂对大鼠皮肤伤口愈合均显示出有益作用，但B/SJW以更全面、更有效的方式影响皮肤修复过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/5a2726430aff/gels-10-00341-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/8b454cc219a6/gels-10-00341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/0dbb4047c7b8/gels-10-00341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/00a4a9d0dfae/gels-10-00341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/b3d834823c21/gels-10-00341-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/d560fcb20798/gels-10-00341-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/5a2726430aff/gels-10-00341-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/8b454cc219a6/gels-10-00341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/0dbb4047c7b8/gels-10-00341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/00a4a9d0dfae/gels-10-00341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/b3d834823c21/gels-10-00341-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/d560fcb20798/gels-10-00341-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d2b/11121646/5a2726430aff/gels-10-00341-g006.jpg

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