Ranjbar Reza, Salighehzadeh Reza, Sharifiyazdi Hassan
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran.
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz 7144169155, Iran.
Antibiotics (Basel). 2019 Oct 28;8(4):198. doi: 10.3390/antibiotics8040198.
spp. is one of the major pathogens of freshwater animals. There has been little research on the genetics of antimicrobial resistance associated with it in Iranian aquaculture. To remedy this lack in research, 74 multi-drug-resistant spp. were isolated from farmed diseased carp, trout, sturgeon, ornamental fish, crayfish, and corresponding water samples and examined for genomic integron sequences. Class 1 integrons, containing seven types of integron cassette arrays (, , , , , , ) were found in 15% of the resistant isolates; no class 2 integrons were detected in any of the resistant isolates. As some tested isolates were resistant to more than two groups of antibiotics, our results demonstrated that freshwater animals in Iran could be a source of multiply drug-resistant spp. This finding suggests that the origin of the antimicrobial resistance of these animals be placed under increased surveillance in the future and that the use of antimicrobials be limited in aquaculture.
某菌属是淡水动物的主要病原体之一。在伊朗水产养殖中，关于与其相关的抗菌药物耐药性遗传学研究甚少。为弥补这一研究空白，从养殖的患病鲤鱼、鳟鱼、鲟鱼、观赏鱼、小龙虾及相应水样中分离出74株多重耐药某菌属菌株，并对其基因组整合子序列进行检测。在15%的耐药菌株中发现了1类整合子，包含7种类型的整合子盒阵列（具体阵列类型未给出）；在任何耐药菌株中均未检测到2类整合子。由于一些受试菌株对两组以上抗生素耐药，我们的结果表明伊朗的淡水动物可能是多重耐药某菌属的来源。这一发现表明，未来应加强对这些动物抗菌药物耐药性来源的监测，并限制水产养殖中抗菌药物的使用。
