Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China.
Department of Anatomy, School of Basic Medical Science, Guizhou Medical University, Guiyang 550025, China.
Sensors (Basel). 2019 Oct 28;19(21):4673. doi: 10.3390/s19214673.
Behavioral assessment, such as systematic scoring or biomechanical measurement, is often used to evaluate the extent of the damage and the degree of recovery after spinal cord injury. However, the use of these methods in standardized evaluation is limited because they are subjective and require complex test systems to implement. Here, we report a novel, flexible, microstructure-based pressure sensor and demonstrate its superior sensitivity (235.12 kPa for 5.5135 Pa and 2.24 kPa for 0.625 kPa), good waterproofness, fast response and recovery times (response time: 8 ms, recovery time: 12 ms), stable response over 8000 loading/unloading cycles, and wide sensing range. These features readily allow the sensor to be comfortably attached to the hindlimbs of mice for full-range, real-time detection of their behavior, such as crawling and swimming, helping to realize quantitative evaluation of animal motor function recovery after spinal cord injury.
行为评估，如系统评分或生物力学测量，通常用于评估脊髓损伤后的损伤程度和恢复程度。然而，由于这些方法具有主观性，并且需要复杂的测试系统来实施，因此在标准化评估中的使用受到限制。在这里，我们报告了一种新颖的、灵活的基于微观结构的压力传感器，并证明了它具有优越的灵敏度（5.5135 Pa 时为 235.12 kPa，0.625 kPa 时为 2.24 kPa）、良好的防水性、快速的响应和恢复时间（响应时间：8 ms，恢复时间：12 ms）、8000 次以上的加载/卸载循环的稳定响应，以及较宽的传感范围。这些特性使得传感器能够舒适地附着在小鼠的后腿上，对其爬行和游泳等行为进行全范围、实时检测，有助于实现脊髓损伤后动物运动功能恢复的定量评估。
